Alcalay J, Bucana C, Kripke M L
Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Photodermatol Photoimmunol Photomed. 1990 Feb;7(1):28-31.
A pigmented melanocytic tumor was induced on the treated site of a C3H/HeN female mouse given repeated topical applications of 8-methoxy-psoralen and subsequent exposures to ultraviolet A radiation (PUVA) over a 7-month period. The tumor invaded the subcutaneous tissue and muscle but produced no distant metastases. To our knowledge, this is the first report suggesting a direct relationship between PUVA treatment and the induction of cutaneous melanocytic tumor in mice.
在一只C3H/HeN雌性小鼠的治疗部位诱发了一种色素性黑素细胞肿瘤，该小鼠在7个月的时间里反复局部应用8-甲氧基补骨脂素，随后暴露于紫外线A辐射（PUVA）下。肿瘤侵犯了皮下组织和肌肉，但未发生远处转移。据我们所知，这是第一份表明PUVA治疗与小鼠皮肤黑素细胞肿瘤诱发之间存在直接关系的报告。
