Sultan S, Chua B Y C, Hamada N, Hynes N
Department of Vascular and Endovascular Surgery, Western Vascular Institute WVI, University College Hospital, Galway UCHG, Newcastle Road, Galway, Ireland.
Int Angiol. 2013 Jun;32(3):281-90.
The aim of this paper was to determine prevalence and incidence of intervention required for concomitant Asymptomatic Vascular Disease (AVD) on patients undergoing their first elective peripheral arterial intervention.
This is a prospective observational study Data was obtained on patients undergoing peripheral revascularisation, abdominal aortic aneurysmal (AAA) repair or carotid procedure from 2006 to 2009. Of 542 complex arterial procedures, 328 patients had their first vascular intervention. (PAD=127, AAA=97, CAD=83, concomitant AAA and PAD=21). Primary endpoint is detection of any concomitant asymptomatic AAA, CAS or PAD. Secondary endpoints are need for intervention of AVD detected on screening, and major adverse clinical events during follow-up.
Prevalence of AVD detected was 13% PAD, 51% CAS and 8%AAA. Symptomatic and Asymptomatic PolyVasBed patients had 11.4- and 8.16-fold increased likelihood for detection of asymptomatic CAS respectively (P<0.0001) relative to the remaining study population. Asymptomatic PolyVasBed patients had 8.2 fold increased likelihood of asymptomatic AAA, P<0.0001, compared to the remaining study population. Likelihood for intervention in Asymptomatic PolyVasBed is OR 5.740 (P=0.044) and Symptomatic PolyVasBed is OR 4.500 (P<0.001). Asymptomatic AAA detected in both symptomatic and asymptomatic vascular disease patients, is the strongest predicting factor of intervention in 18 months follow-up. In Asymptomatic PolyVasBed patients, CAS and AAA have the highest prevalence.
Screening for AVD is mandatory prior to any vascular intervention.
本文旨在确定首次接受择期外周动脉介入治疗的患者中,合并无症状血管疾病(AVD)所需干预的患病率和发病率。
这是一项前瞻性观察性研究。收集了2006年至2009年接受外周血管重建、腹主动脉瘤(AAA)修复或颈动脉手术患者的数据。在542例复杂动脉手术中,328例患者接受了首次血管介入治疗。(外周动脉疾病=127例,腹主动脉瘤=97例,冠状动脉疾病=83例,合并腹主动脉瘤和外周动脉疾病=21例)。主要终点是检测任何合并的无症状腹主动脉瘤、颈动脉粥样硬化(CAS)或外周动脉疾病。次要终点是筛查时检测到的AVD的干预需求,以及随访期间的主要不良临床事件。
检测到的AVD患病率为外周动脉疾病13%、CAS 51%和腹主动脉瘤8%。有症状和无症状的多血管床患者检测到无症状CAS的可能性分别比其余研究人群高11.4倍和8.16倍(P<0.0001)。与其余研究人群相比,无症状多血管床患者无症状腹主动脉瘤的可能性高8.2倍,P<0.0001。无症状多血管床患者干预的可能性为比值比5.740(P=0.044),有症状多血管床患者为比值比4.500(P<0.001)。在有症状和无症状血管疾病患者中检测到的无症状腹主动脉瘤,是18个月随访中干预的最强预测因素。在无症状多血管床患者中,CAS和腹主动脉瘤的患病率最高。
在进行任何血管介入治疗之前,必须对AVD进行筛查。