Saano V, Muranen A, Nuutinen J, Karttunen P, Silvasti M
Department of Pharmacology and Toxicology, University of Kuopio, Finland.
Pharmacol Toxicol. 1990 Apr;66(4):303-6. doi: 10.1111/j.1600-0773.1990.tb00752.x.
The effect of the intravenous administration of ATP on the airway ciliary beating frequency (CBF) of anaesthetized rat was studied by measuring CBF photoelectrically from the inner surface of incised trachea. ATP (1 or 10 mg/kg) caused no changes in the CBF, but the decrease in CBF, which was seen after 70 min. in control rats, was abolished by ATP (10 mg/kg). ATP acutely decreased blood pressure; at 10 mg/kg, the decrease was 70 mmHg in systolic, and 60 mmHg in diastolic blood pressure. ATP also tended to increase rectal temperature and airway resistance, but these effects were not significant. ECG remained normal. Intravenous administration of ATP helps to maintain the function of tracheal cilia in anaesthetized rats at doses that, although lower blood pressure, do not cause fatal untoward effects.
通过光电测量切开气管内表面的气道纤毛摆动频率（CBF），研究了静脉注射三磷酸腺苷（ATP）对麻醉大鼠气道纤毛摆动频率的影响。ATP（1或10mg/kg）对CBF无影响，但在对照大鼠70分钟后出现的CBF降低被ATP（10mg/kg）消除。ATP可使血压急剧下降；10mg/kg时，收缩压下降70mmHg，舒张压下降60mmHg。ATP还倾向于使直肠温度和气道阻力升高，但这些作用不显著。心电图保持正常。静脉注射ATP有助于维持麻醉大鼠气管纤毛的功能，其剂量虽会降低血压，但不会引起致命的不良影响。
