• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

调节性T细胞与血管化骨髓移植联合治疗可产生混合嵌合体，并在无细胞减灭预处理的情况下诱导对血管化复合异体移植物的供体特异性耐受。

Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning.

作者信息

Lin Jeng-Yee, Tsai Feng-Chou, Wallace Christopher Glenn, Huang Wei-Chao, Wei Fu-Chan, Liao Shuen-Kuei

机构信息

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

出版信息

Chimerism. 2013 Jan-Mar;4(1):20-2. doi: 10.4161/chim.23349.

DOI:10.4161/chim.23349
PMID:23712382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3654733/
Abstract

We demonstrate herein that combination treatment with regulatory T cells (Tregs) and vascularized bone marrow transplantation (VBMT) can achieve stable mixed chimerism and long-term transplantation tolerance to vascularized composite allografts (VCA) without requiring cytoreductive recipient conditioning in rats. An appreciable number of Tregs of recipient origin was shown at the interface between recipient and transplanted VCA tissues, implicating a significant role for Tregs in protecting VCA from rejection. This cytoreduction-free protocol using co-treatment with Tregs and VBMT warrants further investigation toward potential clinical application for VCA transplantation.

摘要

我们在此证明，在大鼠中，调节性T细胞（Tregs）与血管化骨髓移植（VBMT）联合治疗可实现稳定的混合嵌合体，并对血管化复合异体移植物（VCA）产生长期移植耐受性，而无需对受体进行细胞减灭预处理。在受体与移植的VCA组织之间的界面处显示出相当数量的受体来源的Tregs，这表明Tregs在保护VCA免受排斥方面发挥着重要作用。这种使用Tregs和VBMT联合治疗的无细胞减灭方案值得进一步研究，以探索其在VCA移植中的潜在临床应用。

相似文献

1
Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning.调节性T细胞与血管化骨髓移植联合治疗可产生混合嵌合体，并在无细胞减灭预处理的情况下诱导对血管化复合异体移植物的供体特异性耐受。
Chimerism. 2013 Jan-Mar;4(1):20-2. doi: 10.4161/chim.23349.
2
Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning.联合调节性 T 细胞和带血管化骨髓移植可产生混合嵌合体，并在不进行细胞消减预处理的情况下诱导对带血管化复合异体移植物的供体特异性耐受。
J Surg Res. 2012 Dec;178(2):974-81. doi: 10.1016/j.jss.2012.06.061. Epub 2012 Jul 11.
3
Commentary on "Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning".
J Surg Res. 2013 Nov;185(1):e37-8. doi: 10.1016/j.jss.2012.07.039. Epub 2012 Aug 4.
4
A novel rat full-thickness hemi-abdominal wall/hindlimb osteomyocutaneous combined flap: influence of allograft mass and vascularized bone marrow content on vascularized composite allograft survival.一种新型大鼠全层半腹壁/后肢骨肌皮联合皮瓣：同种异体移植物质量和带血管骨髓含量对血管化复合组织异体移植存活的影响。
Transpl Int. 2014 Sep;27(9):977-86. doi: 10.1111/tri.12364. Epub 2014 Jul 29.
5
Toward Development of the Delayed Tolerance Induction Protocol for Vascularized Composite Allografts in Nonhuman Primates.朝向建立非人类灵长类动物血管化复合异体移植物延迟耐受诱导方案。
Plast Reconstr Surg. 2020 Apr;145(4):757e-768e. doi: 10.1097/PRS.0000000000006676.
6
Effect of the vascularized bone components on the survival of vascularized composite allografts.带血管骨成分对带血管异体复合组织移植存活的影响。
J Surg Res. 2018 Apr;224:132-138. doi: 10.1016/j.jss.2017.03.050. Epub 2017 Apr 6.
7
Vascularized osteomyocutaneous allografts are permissive to tolerance by induction-based immunomodulatory therapy.带血管化的同种异体骨肌皮瓣可通过诱导性免疫调节治疗实现免疫耐受。
Am J Transplant. 2013 Aug;13(8):2161-8. doi: 10.1111/ajt.12275. Epub 2013 May 29.
8
T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerism model.调节性 T 细胞治疗可预防嵌合鼠模型中心脏同种异体移植物的慢性排斥反应。
J Heart Lung Transplant. 2014 Apr;33(4):429-37. doi: 10.1016/j.healun.2013.11.004. Epub 2013 Nov 28.
9
The reversed paradigm of chimerism induction: Donor conditioning with recipient-derived bone marrow cells as a novel approach for tolerance induction in vascularized composite allotransplantation.嵌合诱导的反向模式：用受体来源的骨髓细胞对供体进行预处理作为血管化复合组织同种异体移植中诱导耐受的新方法。
Microsurgery. 2016 Nov;36(8):676-683. doi: 10.1002/micr.30041. Epub 2016 Mar 14.
10
Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance.非清髓预处理大鼠同时进行骨髓和复合组织移植可促进免疫耐受。
Transplantation. 2013 Jan 27;95(2):301-8. doi: 10.1097/TP.0b013e31827899fc.

引用本文的文献

1
Immunogenicity and tolerance induction in vascularized composite allotransplantation.血管化复合组织同种异体移植中的免疫原性与免疫耐受诱导
Front Transplant. 2024 Feb 13;3:1350546. doi: 10.3389/frtra.2024.1350546. eCollection 2024.
2
CD4CD25FOXP3 regulatory T cells: a potential "armor" to shield "transplanted allografts" in the war against ischemia reperfusion injury.CD4CD25FOXP3 调节性 T 细胞：在对抗缺血再灌注损伤的战争中，可能成为保护“移植同种异体移植物”的“盔甲”。
Front Immunol. 2023 Oct 6;14:1270300. doi: 10.3389/fimmu.2023.1270300. eCollection 2023.
3
Vascularized Thymosternal Composite Tissue Allo- and Xenotransplantation in Nonhuman Primates: Initial Experience.非人灵长类动物的血管化胸腺胸骨复合组织同种异体和异种移植：初步经验。
Plast Reconstr Surg Glob Open. 2017 Dec 22;5(12):e1538. doi: 10.1097/GOX.0000000000001538. eCollection 2017 Dec.

本文引用的文献

1
Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning.联合调节性 T 细胞和带血管化骨髓移植可产生混合嵌合体，并在不进行细胞消减预处理的情况下诱导对带血管化复合异体移植物的供体特异性耐受。
J Surg Res. 2012 Dec;178(2):974-81. doi: 10.1016/j.jss.2012.06.061. Epub 2012 Jul 11.
2
Optimizing chimerism level through bone marrow transplantation and irradiation to induce long-term tolerance to composite tissue allotransplantation.通过骨髓移植和照射来优化嵌合体水平，以诱导对复合组织同种异体移植的长期耐受。
J Surg Res. 2012 Nov;178(1):487-93. doi: 10.1016/j.jss.2012.02.064. Epub 2012 Mar 17.
3
Evidence that FoxP3+ regulatory T cells may play a role in promoting long-term acceptance of composite tissue allotransplants.证据表明，FoxP3+ 调节性 T 细胞可能在促进复合组织同种异体移植的长期接受中发挥作用。
Transplantation. 2011 Apr 27;91(8):908-15. doi: 10.1097/TP.0b013e31820fafb4.
4
Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning.Treg-疗法可在不进行细胞减少性调理的情况下实现混合嵌合和移植耐受。
Am J Transplant. 2010 Apr;10(4):751-762. doi: 10.1111/j.1600-6143.2010.03018.x. Epub 2010 Feb 10.
5
Indoleamine 2,3-dioxygenase and foxp3 expression in skin rejection of human hand allografts.吲哚胺2,3-双加氧酶和叉头框蛋白3在人手部同种异体移植皮肤排斥反应中的表达
Transplant Proc. 2009 Mar;41(2):509-12. doi: 10.1016/j.transproceed.2009.01.008.
6
HLA-mismatched renal transplantation without maintenance immunosuppression.无维持免疫抑制的HLA错配肾移植
N Engl J Med. 2008 Jan 24;358(4):353-61. doi: 10.1056/NEJMoa071074.
7
Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation.
Transplantation. 2006 Dec 27;82(12):1764-8. doi: 10.1097/01.tp.0000250937.46187.ca.
8
Actively acquired tolerance of foreign cells.对外源细胞的主动获得性耐受。
Nature. 1953 Oct 3;172(4379):603-6. doi: 10.1038/172603a0.
9
Mixed allogeneic chimerism in the rat. Donor-specific transplantation tolerance without chronic rejection for primarily vascularized cardiac allografts.大鼠中的混合异基因嵌合体。主要血管化心脏同种异体移植物的供体特异性移植耐受且无慢性排斥反应。
Transplantation. 1995 Nov 15;60(9):971-80.
10
Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen.非致死性预处理方案诱导的混合嵌合状态与永久性特异性移植耐受
J Exp Med. 1989 Feb 1;169(2):493-502. doi: 10.1084/jem.169.2.493.