Kluth L A, Rink M, Ahyai S A, Fisch M, Shariat S F, Dahm P
Klinik für Urologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
Urologe A. 2013 Aug;52(8):1080-3. doi: 10.1007/s00120-013-3144-2.
Randomized controlled trials (RCTs) stopped prematurely for beneficial therapy effects are becoming increasingly more prevalent in the urological literature and often receive great attention in the public and medical media. Urologists who practice evidence-based medicine should be aware of the potential bias and the different reasons why and how early termination of RCTs can and will affect the results. This review provides insights into the challenges clinical urologists face by interpreting the results of prematurely terminated RCTs.
因有益治疗效果而提前终止的随机对照试验（RCTs）在泌尿外科文献中越来越普遍，并且常常在公众和医学媒体中受到极大关注。践行循证医学的泌尿外科医生应该意识到其中潜在的偏倚，以及随机对照试验提前终止的原因、方式及其如何能够并将会影响结果。本综述深入探讨了临床泌尿外科医生在解读提前终止的随机对照试验结果时所面临的挑战。
