Telethon Institute of Genetics and Medicine, Naples, Italy.
Bioessays. 2013 Jul;35(7):612-22. doi: 10.1002/bies.201200180. Epub 2013 May 27.
Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol-4-phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will discuss selected examples of the findings that in the last few years have significantly increased our awareness of the regulation and roles of PI4P in the Golgi complex and beyond. We will also highlight the role of PI4P in infection and cancer. We believe that, with the increasing number of regulators and effectors of PI4P identified, the time is ripe for a more integrated approach of study. A first step in this direction is the delineation of PI4P-centered molecular networks that we provide using data from low and high throughput studies in yeast and mammals.
最初被确定为控制高尔基体膜运输的关键磷酸肌醇，磷脂酰肌醇-4-磷酸（PI4P）已成为调节多种细胞功能的关键分子。在这篇综述中，我们将讨论过去几年中一些发现的例子，这些发现显著提高了我们对 PI4P 在高尔基体及其它细胞器中的调节和作用的认识。我们还将强调 PI4P 在感染和癌症中的作用。我们相信，随着越来越多的 PI4P 调节剂和效应物的被发现，现在是时候采用更综合的研究方法了。朝这个方向迈出的第一步是使用来自酵母和哺乳动物的低和高通量研究的数据，描绘以 PI4P 为中心的分子网络。
