Strutyns'kyĭ R B, Rovenets' R A, Strutyns'ka N A, Neshcheret O P, Moĭbenko O O
Fiziol Zh (1994). 2013;59(1):11-6.
In experiments on the anaesthetized dogs the influence of a new fluorine-containing opener of ATP-sensitive potassium (K(ATP)) channels flocalin on the cardiohemodynamic of great animals in vivo was studied. Flocalin introduced intravenously in doses 0.01 - 1.5 mgs/kg. It is shown that it reduces in dose-dependent manner a system arterial pressure, perfusion pressure in coronary artery and general peripheral resistance of vessels with maximal effects on 56.8 +/- 2.7, 22.4 +/- 4.7 and 47.2% +/- 6.5% accordingly at most dose 1.5 mgs/kg. Flocalin causes development of cardiodepressive reactions in heart, that is exhibited in dose-dependent the decrease of pressure in the left ventricle, speed of growth (dP/dt(max)) and reduction (dP/dt(min)) in it's of pressure with maximal effects on 37.1 +/- 5.1, 51.2 +/- 9.4 and 55.6% +/- 6.9% accordingly at introduction of most dose of flocalin. Diminish of the cardiac out put and heart rate with a maximal effects on 23.1% +/-12.7% and 19.2% +/- 1.7% accordingly at a dose 1.0 mgs/kg was shown. It should be noted that considerable reduction of heart rate and general peripheral resistance of vessels takes place only at the large doses of flocalin - 1 and 1.5 mgs/kg. Thus, it is shown that activation of K(ATP) channels by flocalin causes the dose-dependent decrease of pressure in the system of circulation of blood and contraction activity of myocardium.
在对麻醉犬进行的实验中，研究了一种新型含氟ATP敏感性钾（K(ATP)）通道开放剂氟卡林对大型动物体内心脏血流动力学的影响。氟卡林以0.01 - 1.5毫克/千克的剂量静脉注射。结果表明，它以剂量依赖性方式降低系统动脉压、冠状动脉灌注压和血管总外周阻力，在最大剂量1.5毫克/千克时，最大效应分别为56.8±2.7%、22.4±4.7%和47.2%±6.5%。氟卡林导致心脏出现心脏抑制反应，表现为左心室压力、压力上升速度（dP/dt(max)）和下降速度（dP/dt(min)）呈剂量依赖性降低，在注射最大剂量氟卡林时，最大效应分别为37.1±5.1%、51.2±9.4%和55.6%±6.9%。在剂量为1.0毫克/千克时，心输出量和心率降低，最大效应分别为23.1%±12.7%和19.2%±1.7%。应当指出，只有在大剂量（1和1.5毫克/千克）的氟卡林作用下，心率和血管总外周阻力才会显著降低。因此，研究表明氟卡林激活K(ATP)通道会导致血液循坏系统压力和心肌收缩活动呈剂量依赖性降低。
