Modjtahedi Bobeck S, Maibach Howard, Park Susanna
Department of Ophthalmology and Vision Science, University of California, Davis, Eye Center, Sacramento, CA, USA.
Cutan Ocul Toxicol. 2013 Oct;32(4):341-3. doi: 10.3109/15569527.2013.781618. Epub 2013 May 28.
Choroidal neovascularization membrane (CNVM) is a significant cause of ocular morbidity. Immunologic mechanisms have been proposed in the development of these lesions in exudative age related macular degeneration. Here, we describe the case of an 81-year-old man receiving ipilimumab, an immune modulating drug that enhances T cell response, for metastatic melanoma who developed three simultaneous CNVM bilaterally. This is the first case of ipilimumab-associated CNVM as well as the first case of an immune modulating drug possibly causing CNVM to our knowledge.
脉络膜新生血管膜（CNVM）是导致眼部发病的一个重要原因。免疫机制被认为与渗出性年龄相关性黄斑变性中这些病变的发生有关。在此，我们描述了一名81岁男性的病例，该患者因转移性黑色素瘤接受免疫调节药物伊匹单抗治疗，该药可增强T细胞反应，结果双侧同时出现了三处CNVM。据我们所知，这是首例伊匹单抗相关性CNVM病例，也是首例可能由免疫调节药物导致CNVM的病例。
