Mavissakalian M, Jones B, Olson S, Perel J M
Department of Psychiatry, The Ohio State University College of Medicine, Columbus 43210.
Psychopharmacol Bull. 1990;26(1):119-22.
The clinical significance of the effects of pharmacotherapy and the relationship between plasma tricyclic concentrations and outcome in 33 obsessive-compulsive disorder (OCD) patients who completed 10 weeks of treatment with clomipramine (239.4 +/- 57.0 mg/day) were analyzed. Results revealed that at the end of treatment, OCD symptoms had decreased to a subclinical level in 15 (47%) patients and that nearly 33 percent of the sample was virtually symptom free. However, 1 out of 4 patients failed to improve. Analysis of plasma levels (clomipramine 169.9 +/- 102.1 ng/ml; N-desmethylclomipramine 379.0 +/- 160.6 ng/ml) revealed that responders had significantly higher clomipramine levels and a trend toward lower desmethylclomipramine/clomipramine ratios. A significant degree of correlation was also obtained between plasma levels of clomipramine, but not N-desmethylclomipramine, and post-treatment outcome measures.
分析了33例强迫症（OCD）患者接受10周氯米帕明（239.4±57.0毫克/天）治疗后药物治疗效果的临床意义以及血浆三环类药物浓度与治疗结果之间的关系。结果显示，治疗结束时，15例（47%）患者的强迫症症状已降至亚临床水平，近33%的样本几乎没有症状。然而，四分之一的患者治疗无效。血浆水平分析（氯米帕明169.9±102.1纳克/毫升；去甲氯米帕明379.0±160.6纳克/毫升）显示，有反应者的氯米帕明水平显著更高，而去甲氯米帕明/氯米帕明比值有降低趋势。氯米帕明而非去甲氯米帕明的血浆水平与治疗后结果测量之间也存在显著程度的相关性。
