Wu S G, Miyamoto T
Hospital, National Institute of Radiological Sciences, Chiba City, Japan.
Radiat Res. 1990 Jul;123(1):112-5.
Recombinant human interleukin-1 alpha (rHIL-1 alpha or IL-1) protected the intestinal crypt cells of mice against X-ray-induced damage. The survival of crypt cells measured in terms of their ability to form colonies of regenerating duodenal epithelium in situ was increased when IL-1 was given either before or after irradiation. The maximum degree of radioprotection was seen when the drug was given between 13 and 25 h before irradiation. The IL-1 dose producing maximum protection was about 6.3 micrograms/kg. This is the first report indicating that the cytokine IL-1 has a radioprotective effect in the intestine. The finding suggests that IL-1 may be of potential value in preventing radiation injury to the gut in the clinic.
重组人白细胞介素-1α（rHIL-1α或IL-1）可保护小鼠肠道隐窝细胞免受X射线诱导的损伤。当在照射前或照射后给予IL-1时，根据隐窝细胞在原位形成十二指肠上皮再生集落的能力来衡量，隐窝细胞的存活率会增加。当在照射前13至25小时给予该药物时，可观察到最大程度的辐射防护作用。产生最大保护作用的IL-1剂量约为6.3微克/千克。这是第一份表明细胞因子IL-1在肠道中具有辐射防护作用的报告。这一发现表明，IL-1在临床上预防肠道辐射损伤方面可能具有潜在价值。
