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[长期接受γ射线照射的小鼠组织中核DNA聚合酶活性的增加]

[Increase in the activity of nuclear DNA polymerases in the tissues of mice subjected to long-term gamma irradiation].

作者信息

Kozhanovskaia Ia K, Fomenko L A, Gaziev A I

出版信息

Radiobiologiia. 1990 May-Jun;30(3):300-4.

PMID:2371386
Abstract

Activity of nuclear DNA-polymerase in the liver, lung and spleen tissues of mice subjected to long-term chronic gamma-irradiation (1.3 mGy/h) has been investigated. Chronic gamma-irradiation with a cumulative dose of 1.7 Gy during 55 days raises DNA polymerase activity in the irradiated tissue nuclei. Analysis of DNA-polymerase activity in the liver nuclei have demonstrated that this increase is connected with activation of DNA-polymerase beta.

摘要

对长期慢性γ射线照射(1.3毫戈瑞/小时)的小鼠肝脏、肺和脾脏组织中的核DNA聚合酶活性进行了研究。在55天内累积剂量为1.7戈瑞的慢性γ射线照射提高了受照射组织细胞核中的DNA聚合酶活性。对肝细胞核中DNA聚合酶活性的分析表明,这种增加与DNA聚合酶β的激活有关。

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