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[分裂细胞的间期死亡。间期死亡与细胞能量需求的关系]

[The interphase death of dividing cells. The relation of interphase death to cell energy requirements].

作者信息

Degtiareva O V, Korystov Iu N, Kublik L N, Veksler A M, Dobrovinskaia O R, Eĭdus L Kh

出版信息

Radiobiologiia. 1990 May-Jun;30(3):407-10.

PMID:2371401
Abstract

In experiments with irradiated cells of Chinese hamster and Ehrlich ascites tumor a study was made of the influence of energy provision on their interphase death rate. The presence of the uncoupler of respiration and oxidative phosphorylation--carbonyl cyanide-3-chlorophenylhydrazone--in a medium without glucose was shown to drastically increase the interphase death rate of cells of both types, whereas this effect was not observed in a medium with glucose.

摘要

在用中国仓鼠和艾氏腹水瘤的辐照细胞进行的实验中,研究了能量供应对其间期死亡率的影响。结果表明,在不含葡萄糖的培养基中存在呼吸和氧化磷酸化解偶联剂——羰基氰化物-3-氯苯腙,会显著提高两种类型细胞的间期死亡率,而在含葡萄糖的培养基中未观察到这种效应。

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