Holden B A, Sweeney D F, Swarbrick H A, Vannas A, Nilsson K T, Efron N
Cornea and Contact Lens Research Unit, School of Optometry, University of New South Wales, Sydney, New South Wales, AustraliaUniversity Eye Clinic, Helsinki, FinlandContacta Optik, Gothenberg, Sweden.
Clin Exp Optom. 1986 May;69(3):112-9. doi: 10.1111/j.1444-0938.1986.tb06800.x.
The effects of long-term extended wear of soft contact lenses on human conjunctival and limbal vasculature were determined by examining 27 patients who had worn a high water content hydrogel contact lens in one eye only for an average of 62 ± 29 months (mean ± SD). The levels of general conjunctival hyperaemia (p > 0.01), limbal hyperaemia (p > 0.001), and the extent of limbal vessel penetration (p > 0.001) were found to be significantly greater in the lens-wearing eye, relative to the control eye, immediately on lens removal. The patients ceased lens wear for up to one month, and changes in the levels of vascular response were monitored during this period. General conjunctival hyperaemia and limbal hyperaemia recovered to levels observed in the non-lens-wearing eye within two and seven days after lens removal, respectively. However, limbal vessel penetration was still significantly greater in the lens-wearing eye 33 days after ceasing lens wear (p > 0.05).
通过检查27例患者来确定长期延长佩戴软性隐形眼镜对人结膜和角膜缘血管系统的影响，这些患者仅在一只眼睛中佩戴高含水量水凝胶隐形眼镜，平均佩戴时间为62±29个月（平均值±标准差）。在摘除隐形眼镜后立即发现，与对照眼相比，佩戴隐形眼镜眼的结膜充血程度（p>0.01）、角膜缘充血程度（p>0.001）和角膜缘血管侵入程度（p>0.001）明显更高。患者停止佩戴隐形眼镜长达一个月，并在此期间监测血管反应水平的变化。结膜充血和角膜缘充血分别在摘除隐形眼镜后的两天和七天内恢复到未佩戴隐形眼镜眼观察到的水平。然而，在停止佩戴隐形眼镜33天后，佩戴隐形眼镜眼的角膜缘血管侵入仍明显更高（p>0.05）。
