Hoelzer Dieter
From ONKOLOGIKUM, Frankfurt, Germany.
Am Soc Clin Oncol Educ Book. 2013:290-3. doi: 10.14694/EdBook_AM.2013.33.290.
In adult acute lymphoblastic leukemia (ALL) the complete remission (CR) rates have improved to 85% to 90%. Despite this high CR rate, 40% to 50% of patients eventually relapse. This occurs because of the limited sensitivity of cytomorphology in assessing complete molecular remission. Thus, more sensitive methods that detect leukemic cells on a molecular level and identify minimal residual disease are needed.
在成人急性淋巴细胞白血病（ALL）中，完全缓解（CR）率已提高到85%至90%。尽管CR率很高，但仍有40%至50%的患者最终复发。这是因为细胞形态学在评估完全分子缓解方面的敏感性有限。因此，需要更敏感的方法在分子水平上检测白血病细胞并识别微小残留病。
