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有限剂量经皮吸收数据的分析：对经皮暴露评估的影响。

Analysis of finite dose dermal absorption data: implications for dermal exposure assessment.

机构信息

Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, WV, USA.

Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, OH, USA.

出版信息

J Expo Sci Environ Epidemiol. 2014 Jan-Feb;24(1):65-73. doi: 10.1038/jes.2013.23. Epub 2013 May 29.

DOI:10.1038/jes.2013.23
PMID:23715085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3868874/
Abstract

A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied chemical that is absorbed, assumed constant for a given chemical. Despite the prominence of this approach there is little guidance regarding the evaluation of experiments from which fractional absorption data are measured. An analysis of these experiments is presented herein, and limitations to the fixed fractional absorption approach are discussed. The analysis provides a set of simple algebraic expressions that may be used in the evaluation of finite dose dermal absorption experiments, affording a more data-driven approach to dermal exposure assessment. Case studies are presented that demonstrate the application of these tools to the assessment of dermal absorption data.

摘要

一种常见的皮肤暴露评估策略是使用固定分数吸收方法来估计与皮肤接触的化学物质的全身吸收

皮肤吸收剂量估计为暴露量和吸收的应用化学物质分数的乘积，对于给定的化学物质，假设为常数。尽管这种方法很常见，但对于评估测量分数吸收数据的实验几乎没有指导。本文对这些实验进行了分析，并讨论了固定分数吸收方法的局限性。该分析提供了一组简单的代数表达式，可用于评估有限剂量皮肤吸收实验，为皮肤暴露评估提供了一种更具数据驱动性的方法。本文还提出了一些案例研究，展示了这些工具在评估皮肤吸收数据中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/108981418419/jes201323f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/1810a02276e0/jes201323f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/9c28f96558ae/jes201323f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/fd14ca94c750/jes201323f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/bec26d387138/jes201323f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/108981418419/jes201323f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/1810a02276e0/jes201323f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/9c28f96558ae/jes201323f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/fd14ca94c750/jes201323f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/bec26d387138/jes201323f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ecb/3868874/108981418419/jes201323f5.jpg

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