Ralph E. Martin Department of Chemical Engineering, University of Arkansas, 3202 Bell Engineering Center, Fayetteville, AR, USA.
Org Biomol Chem. 2013 Jul 21;11(27):4459-64. doi: 10.1039/c3ob40561c.
Peptoids are a versatile family of oligomeric synthetic molecules that can be customized for many applications. The submonomer solid-phase synthesis of peptoids allows for quick and inexpensive manufacturing and the selection of side chains is nearly limitless. In addition, peptoids that include chiral, aromatic side chains form stable helical secondary structure that leads to the potential for the formation of supramolecular assemblies. The effects of water solubility, helical content, charge placement, and side chain bulk on microsphere formation were studied for seven peptoid sequences. We found that secondary structure and partial water solubility were essential for microsphere formation. In addition, charge placement and side chain bulk affect both the ability to form microspheres and the diameter of the microspheres.
肽缩氨酸是一类用途广泛的低聚物合成分子，可针对多种应用进行定制。肽缩氨酸的亚单体固相合成方法可以快速且廉价地制造，并且侧链的选择几乎是无限的。此外，包含手性、芳香侧链的肽缩氨酸形成稳定的螺旋二级结构，从而有可能形成超分子组装体。本文研究了七个肽缩氨酸序列的亲水性、螺旋含量、电荷分布和侧链体积对微球形成的影响。我们发现二级结构和部分亲水性对微球形成至关重要。此外，电荷分布和侧链体积会影响形成微球的能力和微球的直径。
