Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Chem Soc Rev. 2013 Aug 21;42(16):6605-19. doi: 10.1039/c3cs60062a. Epub 2013 May 29.
Vitamin B12 plays a key role in many metabolic processes occurring in all mammals. Over the years its biological role has been extensively studied generating a lot of interest in the chemistry of this vital molecule. This established a variety of new methodologies for the synthesis and analysis of new cobalamin derivatives as well as creative purification techniques. This tutorial review summarizes all the advancements made in this area, providing a deeper insight into vitamin B12 chemistry.
维生素 B12 在所有哺乳动物中发生的许多代谢过程中都起着关键作用。多年来，它的生物学作用已经得到了广泛的研究，这使得人们对这种重要分子的化学性质产生了浓厚的兴趣。这就为新钴胺素衍生物的合成和分析以及创造性的纯化技术建立了各种新的方法。本教程综述总结了该领域的所有进展，深入了解维生素 B12 化学。
