Centre for Genomic Regulation (CRG), and UPF, Dr Aiguader 88, 08003 Barcelona,Spain.
Development. 2013 Jun;140(12):2525-34. doi: 10.1242/dev.091553.
Polycomb group (PcG) proteins are epigenetic modifiers involved in controlling gene repression. Organized within multiprotein complexes, they regulate developmental genes in multiple cell types and tissue contexts, including embryonic and adult stem cells, and are essential for cell fate transitions and proper development. Here, we summarize recent breakthroughs that have revealed the diversity of PcG complexes acting in different cell types and genomic contexts. Intriguingly, it appears that particular PcG proteins have specific functions in embryonic development, in pluripotent stem cells and in reprogramming somatic cells into a pluripotent-like state. Finally, we highlight recent results from analyzing PcG protein functions in multipotent stem cells, such as neural, hematopoietic and epidermal stem cells.
多梳抑制复合物（PcG）蛋白是参与基因沉默调控的表观遗传修饰因子。它们形成多蛋白复合物，在多种细胞类型和组织环境中调节发育基因，包括胚胎和成年干细胞，对于细胞命运转变和正常发育至关重要。在这里，我们总结了最近的一些突破，这些突破揭示了不同细胞类型和基因组环境中发挥作用的 PcG 复合物的多样性。有趣的是，似乎特定的 PcG 蛋白在胚胎发育、多能干细胞和体细胞重编程为多能样状态中具有特定的功能。最后，我们强调了分析多能干细胞中 PcG 蛋白功能的最新结果，如神经、造血和表皮干细胞。
