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择期手术治疗憩室病的结果和费用:与其他需要结肠切除术的疾病的比较。

Outcomes and costs of elective surgery for diverticular disease: a comparison with other diseases requiring colectomy.

机构信息

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

出版信息

JAMA Surg. 2013 Apr;148(4):316-21. doi: 10.1001/jamasurg.2013.1010.

DOI:10.1001/jamasurg.2013.1010
PMID:23715829
Abstract

OBJECTIVE

To compare outcomes and costs of elective surgery for diverticular disease (DD) with those of other diseases commonly requiring colectomy.

DESIGN

Multivariable analyses using the Nationwide Inpatient Sample to compare outcomes across primary diagnosis while adjusting for age, sex, race, year of admission, and comorbid disease.

SETTING

A sample of US hospital admissions from 2003-2009.

PATIENTS

All adult patients (≥18 years) undergoing elective resection of the descending colon or subtotal colectomy who had a primary diagnosis of DD, colon cancer (CC), or inflammatory bowel disease (IBD).

MAIN OUTCOME MEASURES

In-hospital mortality, postoperative complications, ostomy placement, length of stay, and hospital charges.

RESULTS

Of the 74,879 patients, 50.52% had DD, 43.48% had CC, and 6.00% had IBD. After adjusting for other variables, patients with DD were significantly more likely than patients with CC to experience in-hospital mortality (adjusted odds ratio, 1.90; 95% CI, 1.37-2.63; P < .001), develop a postoperative infection (1.67; 1.48-1.89; P < .001), and have an ostomy placed (1.87; 1.65-2.11; P < .001). The adjusted total hospital charges for patients with DD were $6678.78 higher (95% CI, $5722.12-$7635.43; P < .001) and length of stay was 1 day longer (95% CI, 0.86-1.14; P < .001) compared with patients with CC. Patients with IBD had the highest in-hospital mortality, highest rates of complications and ostomy placement, longest length of stay, and highest hospital charges.

CONCLUSIONS

Despite undergoing the same procedure, patients with DD have significantly worse and more costly outcomes after elective colectomy compared with patients with CC but better than patients with IBD. These relatively poor outcomes should be recognized when considering routine elective colectomy after successful nonoperative management of acute diverticulitis.

摘要

目的

比较择期手术治疗憩室病(DD)与其他常见结肠切除术疾病的结局和成本。

设计

使用全国住院患者样本进行多变量分析,比较主要诊断的结果,同时调整年龄、性别、种族、入院年份和合并疾病。

设置

2003-2009 年美国住院患者样本。

患者

所有接受选择性降结肠切除术或次全结肠切除术的成年患者(≥18 岁),其主要诊断为 DD、结肠癌(CC)或炎症性肠病(IBD)。

主要观察指标

院内死亡率、术后并发症、造口术安置、住院时间和住院费用。

结果

在 74879 名患者中,50.52%为 DD,43.48%为 CC,6.00%为 IBD。在调整其他变量后,DD 患者的院内死亡率明显高于 CC 患者(校正优势比,1.90;95%CI,1.37-2.63;P<0.001),发生术后感染的可能性更高(1.67;1.48-1.89;P<0.001),并且更有可能进行造口术(1.87;1.65-2.11;P<0.001)。DD 患者的总住院费用高 6678.78 美元(95%CI,5722.12-7635.43;P<0.001),住院时间长 1 天(95%CI,0.86-1.14;P<0.001)。与 CC 患者相比,IBD 患者的院内死亡率最高,并发症和造口术安置率最高,住院时间最长,住院费用最高。

结论

尽管接受了相同的手术,但与 CC 患者相比,DD 患者在择期结肠切除术后的结局明显更差,费用更高,但比 IBD 患者好。在考虑急性憩室炎成功非手术治疗后常规择期结肠切除时,应认识到这些相对较差的结局。

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