Patient autoantibodies induce platelet destruction signals via raft-associated glycoprotein Ibα and Fc RIIa in immune thrombocytopenia.
作者信息
Urbanus Rolf T, van der Wal Dianne E, Koekman Cornelis A, Huisman Albert, van den Heuvel Dave J, Gerritsen Hans C, Deckmyn Hans, Akkerman Jan-Willem N, Schutgens Roger E G, Gitz Eelo
出版信息
Haematologica. 2013 Jul;98(7):e70-2. doi: 10.3324/haematol.2013.087874. Epub 2013 May 28.
Abstract
摘要
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Patient autoantibodies induce platelet destruction signals via raft-associated glycoprotein Ibα and Fc RIIa in immune thrombocytopenia.在免疫性血小板减少症中，患者自身抗体通过脂筏相关糖蛋白Ibα和Fc RIIa诱导血小板破坏信号。
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The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage.免疫性血小板减少症的免疫发病机制：T 细胞仍然占据中心舞台。
Curr Opin Hematol. 2012 Sep;19(5):357-62. doi: 10.1097/MOH.0b013e3283567541.
2
Improved platelet survival after cold storage by prevention of glycoprotein Ibα clustering in lipid rafts.通过防止糖蛋白 Ibα 在脂筏中聚集来提高冷藏后的血小板存活率。
Haematologica. 2012 Dec;97(12):1873-81. doi: 10.3324/haematol.2012.066290. Epub 2012 Jun 24.
3
Complement activation on platelets correlates with a decrease in circulating immature platelets in patients with immune thrombocytopenic purpura.血小板上补体的激活与免疫性血小板减少性紫癜患者循环中未成熟血小板的减少相关。
Br J Haematol. 2010 Feb;148(4):638-45. doi: 10.1111/j.1365-2141.2009.07995.x. Epub 2009 Nov 19.
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International consensus report on the investigation and management of primary immune thrombocytopenia.国际原发性免疫性血小板减少症诊治共识报告
Blood. 2010 Jan 14;115(2):168-86. doi: 10.1182/blood-2009-06-225565. Epub 2009 Oct 21.
5
Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity.FcγRIIa（CD32a）与脂筏的结合调节配体结合活性。
J Immunol. 2009 Jun 15;182(12):8026-36. doi: 10.4049/jimmunol.0900107.
6
Neutrophils phagocytose activated platelets in vivo: a phosphatidylserine, P-selectin, and {beta}2 integrin-dependent cell clearance program.中性粒细胞在体内吞噬活化血小板：一种磷脂酰丝氨酸、P-选择素和β2整合素依赖性的细胞清除程序。
Blood. 2009 May 21;113(21):5254-65. doi: 10.1182/blood-2008-09-180794. Epub 2009 Mar 4.
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Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management.特发性血小板减少性紫癜：病理生理学与治疗的当前概念
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8
The association between platelet autoantibody specificity and response to intravenous immunoglobulin G in the treatment of patients with immune thrombocytopenia.免疫性血小板减少症患者治疗中血小板自身抗体特异性与静脉注射免疫球蛋白G反应之间的关联。
Haematologica. 2007 Feb;92(2):283-4. doi: 10.3324/haematol.10667.
9
The clearance mechanism of chilled blood platelets.冷保存血小板的清除机制。
Cell. 2003 Jan 10;112(1):87-97. doi: 10.1016/s0092-8674(02)01253-9.
10
Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation.黏附受体糖蛋白Ib-IX-V复合物定位于脂筏是血小板黏附和激活所必需的。
J Exp Med. 2002 Oct 21;196(8):1057-66. doi: 10.1084/jem.20020143.
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