胃内同时性腺癌和胃肠道间质瘤。
Synchronous adenocarcinoma and gastrointestinal stromal tumors in the stomach.
机构信息
Department of Radiochemotherapy, Rui Jin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China.
出版信息
World J Gastroenterol. 2013 May 28;19(20):3117-23. doi: 10.3748/wjg.v19.i20.3117.
AIM
To review the clinicopathological characteristics of concurrent gastrointestinal stromal tumors (GISTs) and gastric adenocarcinoma.
METHODS
We retrospectively analyzed eight cases of synchronous adenocarcinoma and GIST in the stomach that had been surgically resected with curative intent between March 2003 and December 2008 in Xinhua hospital and Ruijin hospital. The adenocarcinoma was determined to be the primary tumor based on the histological features. The GIST cells were diffusely and strongly positive for CD34 and CD117.
RESULTS
The patients were six men and two women aged 47-80 years (average, 68.6 years). GIST was preoperatively detected in only one patient. The average sizes of the gastric adenocarcinomas and GISTs were 6.000 ± 2.6186 cm and 1.825 ± 1.4370 cm, respectively. All GISTs were very low- or low-risk lesions that were detected during evaluation, staging, operation or follow-up for gastric adenocarcinoma.
CONCLUSION
We hypothesized that the stomach was influenced by the same unknown carcinogen, resulting in a simultaneous proliferation of different cell lines (epithelial and stromal cell).
目的
回顾同时性胃肠道间质瘤（GIST）和胃腺癌的临床病理特征。
方法
我们回顾性分析了 2003 年 3 月至 2008 年 12 月期间在新华医院和瑞金医院接受根治性手术切除的 8 例同时性胃腺癌和 GIST 病例。腺癌的原发性肿瘤是根据组织学特征确定的。GIST 细胞弥漫且强烈表达 CD34 和 CD117。
结果
患者为 6 男 2 女，年龄 47-80 岁（平均 68.6 岁）。术前仅 1 例患者检测到 GIST。胃腺癌和 GIST 的平均大小分别为 6.000 ± 2.6186cm 和 1.825 ± 1.4370cm。所有 GIST 在评估、分期、手术或胃腺癌随访期间均被检测为极低或低风险病变。
结论
我们假设胃受到相同未知致癌物的影响，导致不同细胞系（上皮和间质细胞）同时增殖。
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