Christenson J T, Strauss H W
Dept. of Radiology, Massachusetts General Hospital, Boston.
Vasa. 1990;19(2):129-33.
The interaction of blood platelets with artificial surfaces such as vascular grafts, seems to be a major contributing factor for the initiation of thrombus formation. A protein co-factor such as fibrinogen may enhance adhesion of platelets to a foreign surface. In the present study we have investigated the temporal relationship of platelet deposition to that of fibrinogen in small PTFE vascular grafts placed into the circulation of dogs. It was found that while platelet adhesion to PTFE grafts seems to be flow dependent below a threshold velocity, fibrinogen deposition is independent of blood flow. Platelet deposition is non-uniformly distributed along the graft surface, with preferential deposition towards the distal anastomosis, while fibrinogen deposition showed a uniform distributional pattern along the graft surface. Platelet deposition appears to occur independent of fibrinogen deposition.
血小板与诸如血管移植物等人工表面的相互作用，似乎是血栓形成起始的一个主要促成因素。一种蛋白质辅助因子（如纤维蛋白原）可能会增强血小板对外来表面的黏附。在本研究中，我们调查了置于犬循环系统中的小型聚四氟乙烯（PTFE）血管移植物中血小板沉积与纤维蛋白原沉积的时间关系。结果发现，虽然在低于阈值速度时，血小板对PTFE移植物的黏附似乎依赖于血流，但纤维蛋白原的沉积与血流无关。血小板沉积沿移植物表面分布不均匀，在远端吻合口处优先沉积，而纤维蛋白原沉积沿移植物表面呈现均匀的分布模式。血小板沉积似乎独立于纤维蛋白原沉积而发生。
