Lim Seungtaek, Lee Soohyeon, Rha Sun Young, Rho Jae Kyung
Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Asia Pac J Clin Oncol. 2016 Mar;12(1):e149-53. doi: 10.1111/ajco.12072. Epub 2013 May 29.
Craniofacial osteosarcoma is a rare disease accounting for only 1% of all head and neck malignancies. Its clinical features and optimal treatments are not yet clearly established.
We retrospectively analyzed the clinical course of 15 patients with craniofacial osteosarcoma treated in a single institute.
Out of 13 patients who initially underwent primary mass resection, disease recurrence was found in five (36%). Patients with positive surgical margins showed higher recurrence and shorter median recurrence-free and overall survival. Of three patients who had secondary operation after local recurrence, two survived for 44.6 and 64.2 months, respectively. One patient who underwent repeated lung metastasectomy had a disease-free survival of 18.4 months from the first recurrence.
The current study demonstrates that positive surgical margins are important predictive factors for recurrence and overall survival. Salvage surgery for local recurrence and metastasectomy for systemic recurrence might have a positive impact on survival.
