Feng Wenming, Tang Chengwu, Guo Huihui, Bao Ying, Wen Xiaohong, Xue Tao, Gong Hui
Hepatogastroenterology. 2013 Jul-Aug;60(125):1001-5. doi: 10.5754/hge13141.
BACKGROUND/AIMS: This study aims to explore the prognostic value of Serum cholinesterase (SchE) activity in patients with sepsis.
The evaluation variable of APACHE II score was assessed and the SchE concentrations were determined in 359 patients immediately upon admission and 24 hours after admission. All patients were divided into two groups based on their prognosis. The relationships of SchE concentration and APACHE II score with prognosis were analyzed.
The SchE activity was significantly higher (p <0.01) and the APACHE II score was significantly lower (p <0.01) in survivors than in non-survivors. The areas under the receiver operating characteristic curve (AUC) were more than 0.9 for both the loss of SchE activity (delta SchE) and the loss of APACHE II score (delta APACHE II) during 24 h in patients admitted 24 h after onset (D1). The AUC for SchE activity and APACHE II were similar in most groups except hepatobiliary infection group.
The SchE activity and APACHE II score were useful for prognosis of septic patients. Although SchE activity was not as powerful as APACHE II in the prognosis of sepsis, dynamic monitoring of SchE and APACHE II had similar value in outcome prediction.
背景/目的：本研究旨在探讨血清胆碱酯酶（SchE）活性在脓毒症患者中的预后价值。
评估急性生理与慢性健康状况评分系统（APACHE II）的评分变量，并在359例患者入院时及入院24小时后测定SchE浓度。所有患者根据预后分为两组。分析SchE浓度和APACHE II评分与预后的关系。
幸存者的SchE活性显著更高（p<0.01），APACHE II评分显著更低（p<0.01）。发病24小时后入院（D1）的患者在24小时内SchE活性降低（ΔSchE）和APACHE II评分降低（ΔAPACHE II）的受试者工作特征曲线下面积（AUC）均大于0.9。除肝胆感染组外，大多数组中SchE活性和APACHE II的AUC相似。
SchE活性和APACHE II评分对脓毒症患者的预后有参考价值。虽然在脓毒症预后方面SchE活性不如APACHE II强大，但SchE和APACHE II的动态监测在结局预测方面具有相似价值。
