Magnetic Resonance Research Center, Yale School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA.
Physiol Meas. 2013 Jun;34(6):623-44. doi: 10.1088/0967-3334/34/6/623. Epub 2013 May 29.
Imaging the electrical properties of human tissue may aid in cancer diagnoses or monitoring organ function. Traditionally, the electrical properties are revealed with electrical impedance tomography, where currents are injected into human tissue and voltages are measured on the surface. This paper focuses on a method of measuring the electrical properties using a magnetic resonance (MR) scanner without current injection. In magnetic resonance driven electrical impedance tomography (MRDEIT), the MR phenomenon is used to induce currents in the body and the complex permittivity map is inversely computed from the difference between the modeled electric field and the actual surface electrode measurements. Computer simulations indicate that with noise level under 20%, the contrast is visually discernible in the reconstruction image. A phantom experiment is demonstrated and this supports results from computer simulation studies. The noise level in electrode measurements is evaluated to be approximately 7.8% from repeated experiments, confirming the potential to reconstruct conductivity contrast using MRDEIT. With further improvements in hardware and image reconstruction, MRDEIT may provide an additional contrast mechanism reflecting the electrical properties of human tissue, which may ultimately be used to diagnose a cancer or assist in electroencephalography.
对人体组织的电特性进行成像可能有助于癌症诊断或监测器官功能。传统上,通过电阻抗断层成像(electrical impedance tomography,EIT)来揭示电特性,在 EIT 中,电流被注入人体组织,然后在表面测量电压。本文专注于一种无需电流注入即可使用磁共振(magnetic resonance,MR)扫描仪测量电特性的方法。在磁共振驱动的电阻抗断层成像(magnetic resonance driven electrical impedance tomography,MRDEIT)中,磁共振现象用于在体内产生电流,并通过从模型电场和实际表面电极测量之间的差异来反演复介电常数图。计算机模拟表明,在噪声水平低于 20%的情况下,重建图像中的对比度可以通过视觉进行分辨。本文还进行了一项体模实验,实验结果支持了计算机模拟研究的结果。通过对重复实验的电极测量噪声水平进行评估,大约为 7.8%,这证实了使用 MRDEIT 重建电导率对比度的潜力。随着硬件和图像重建的进一步改进,MRDEIT 可能提供反映人体组织电特性的额外对比机制,这最终可能用于诊断癌症或协助脑电图检查。