Ruiz Marco Andres, Reske Tom, Cefalu Charles, Estrada John
Louisiana State University Health Sciences Center, New Orleans, LA, USA.
J Int Assoc Provid AIDS Care. 2013 Jul-Aug;12(4):266-9. doi: 10.1177/2325957413488204. Epub 2013 May 29.
Falls is a common geriatric syndrome that has not been well characterized in HIV-infected populations.
We retrospectively reviewed our database and identified patients who fell over the last 12 months.
Thirty-two patients were identified (incidence rate of 16 × 1000 patients per year). Twenty-five percent were female and 75% male. Sixty-seven percent were African American with 33% Caucasians. Average age was 48.19, number of years with HIV infection on average was 9.38 years, mean CD4 count 347.2 cell/mm(3), mean HIV viral load was 31 379 copies/mL. The average number of medications was 8.7 with a mean of 3.48 comorbidities. The mean vitamin D level was 27.20. Sixty-two percent of patients were compliant with antiretroviral therapy. Univariate and multivariate analysis showed that number of medications (< .005 medications; P < .005), more than 3 comorbidities (P < .005), and noncompliance (P < .001) were related to falls in this population.
Falls is a common geriatric syndrome. Associated risk factors in our cohort included number of medications, more than 3 comorbidities, and noncompliance. Larger studies are needed to properly characterize this geriatric syndrome in HIV-infected patients. As HIV-infected populations age, a shift into a more comprehensive geriatrics care including fall risk evaluation may be needed.
跌倒在老年人群中是一种常见的综合征，但在感染HIV的人群中尚未得到充分描述。
我们回顾性地查阅了我们的数据库，确定了在过去12个月内跌倒的患者。
共确定了32例患者（年发病率为16/1000患者）。25%为女性，75%为男性。67%为非裔美国人，33%为白种人。平均年龄为48.19岁，平均感染HIV的年限为9.38年，平均CD4细胞计数为347.2个/立方毫米，平均HIV病毒载量为31379拷贝/毫升。平均用药数量为8.7种，平均合并症数量为3.48种。平均维生素D水平为27.20。62%的患者依从抗逆转录病毒治疗。单因素和多因素分析表明，用药数量（<0.005种药物；P<0.005）、超过3种合并症（P<0.005）和不依从（P<0.001）与该人群的跌倒有关。
跌倒是一种常见的老年综合征。我们队列中的相关危险因素包括用药数量、超过3种合并症和不依从。需要开展更大规模的研究，以充分描述HIV感染患者中的这种老年综合征。随着感染HIV的人群老龄化，可能需要转向更全面的老年护理，包括跌倒风险评估。
