Bezić Joško, Mrklić Ivana, Pogorelić Zenon, Tomić Snježana
Institute of Pathology, Forensic Medicine and Cytology, Clinical Hospital Center Split, Split, Croatia.
Breast Dis. 2013 Jan 1;34(2):47-51. doi: 10.3233/BD-130349.
The national breast cancer screening program has been introduced in Croatia in the second half of 2006 with mammography as the screening method. We investigated the impact of screening mammography on the basic pathohistological characteristics of breast cancers retrieved from the database of large community hospital. The data were collected in the period following the initiation of national mamographic screening program (2007-2011), and compared with the data collected in the period before the program introduction (2002-2006) to explore the possible changing trends. In the screening period 1,320 breast cancers were diagnosed, while in the prescreening period 1,204 breast cancers were diagnosed (p=0.02). We found the reduction of mean tumor size (p=0.039), decrease of the diagnosed non-invasive cancers (p=0.001), and the higher percentage of the diagnosed ductal (p=0.0003) and grade 3 (p=0.038) invasive cancers in the screening period. We also noticed higher percentage of diagnosed advanced breast cancers with unknown tumor size in the screening period (p=0.027). We concluded that the implementation of national screening program did not improve the pathohistological features of breast cancers in our region probably due to low response rate to screening invitation.
2006年下半年，克罗地亚引入了国家乳腺癌筛查项目，采用乳房X线摄影作为筛查方法。我们调查了筛查性乳房X线摄影对从大型社区医院数据库中获取的乳腺癌基本病理组织学特征的影响。数据收集于国家乳房X线摄影筛查项目启动后的时期（2007 - 2011年），并与项目引入前时期（2002 - 2006年）收集的数据进行比较，以探索可能的变化趋势。在筛查期间，诊断出1320例乳腺癌，而在筛查前时期，诊断出1204例乳腺癌（p = 0.02）。我们发现筛查期间平均肿瘤大小减小（p = 0.039），诊断出的非浸润性癌减少（p = 0.001），以及诊断出的导管浸润性癌（p = 0.0003）和3级浸润性癌（p = 0.038）的百分比更高。我们还注意到筛查期间诊断出的肿瘤大小未知的晚期乳腺癌百分比更高（p = 0.027）。我们得出结论，国家筛查项目的实施并未改善我们地区乳腺癌的病理组织学特征，可能是由于对筛查邀请的响应率较低。
