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[选择性动脉栓塞术治疗妊娠晚期胎盘植入]

[Selective arterial occlusion in the treatment of placenta percreta in late trimester of pregnancy].

作者信息

Zhang Jing, Liu Qiaoshu, Zhang Weishe, Dong Meilian, Wu Xinhua, Wu Zhaodi

机构信息

Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 May;38(5):532-6. doi: 10.3969/j.issn.1672-7347.2013.05.015.

Abstract

OBJECTIVE

To evaluate the value of selective arterial occlusion in the treatment of placenta percreta in late trimester of pregnancy.

METHODS

Fifteen clinical patients ( gestational age ≥34 weeks), diagnosed with placenta percreta in Xiangya Hospital of Central South University from January 2003 to December 2010, were retrospectively analyzed. According to whether the selective arterial occlusion was used or not, the 15 patients were divided into 2 groups: an arterial occlusion group (n=8) and a non-arterial occlusion group (n=7). Based on the time of occlusion, the arterial occlusion group was divided into a prophylactic occlusion subgroup (n=4) and a remedial occlusion subgroup (n=4) (including 1 patient who was performed after the iliac artery balloon was taken out ). The blood loss, the rate of hysterectomy and complications were compared between the arterial occlusion group and the non-arterial occlusion group.

RESULTS

In all 15 patients, the average amount of blood loss was 3813 mL, and the rate of hysterectomy was 73.3% (11/15). The recent complication rate was 20.0% (3/15, including 2 blood coagulation dysfunctions and 1 lower extremity thrombosis), and long-term complication was not found. The average amount of blood loss in the occlusion group was 2512 mL, the hysterectomy rate was 62.5%(5/8); while the average amount of bleeding was 5549 mL and the hysterectomy rate was 85.7% in the non-occlusion group (6/7). There was significant difference between the 2 groups (P<0.05). The average amount of blood loss and the rate of hysterectomy in the prophylactic occlusion subgroup were lower than those in the remedial occlusion subgroup (1350 mL vs 3600 mL, 60.0% vs 66.7%, P<0.05).

CONCLUSION

Patients with placenta percreta in the third trimester of pregnancy may encounter severe postpartum hemorrhage, and the rate of hysterectomy is high. The amount of blood loss and the rate of hysterectomy may be reduced by the selective arterial occlusion before or in the cesarean section, but cannot be avoided completely.

摘要

目的

评估选择性动脉栓塞术在妊娠晚期胎盘植入治疗中的价值。

方法

回顾性分析2003年1月至2010年12月在中南大学湘雅医院诊断为胎盘植入的15例临床患者(孕周≥34周)。根据是否采用选择性动脉栓塞术,将15例患者分为2组:动脉栓塞组(n = 8)和非动脉栓塞组(n = 7)。根据栓塞时间,动脉栓塞组又分为预防性栓塞亚组(n = 4)和补救性栓塞亚组(n = 4)(包括1例在取出髂动脉球囊后进行栓塞的患者)。比较动脉栓塞组和非动脉栓塞组的失血量、子宫切除率及并发症情况。

结果

15例患者中,平均失血量为3813 mL,子宫切除率为73.3%(11/15)。近期并发症发生率为20.0%(3/15,包括2例凝血功能障碍和1例下肢血栓形成),未发现远期并发症。栓塞组平均失血量为2512 mL,子宫切除率为62.5%(5/8);而非栓塞组平均出血量为5549 mL,子宫切除率为85.7%(6/7)。两组间差异有统计学意义(P<0.05)。预防性栓塞亚组的平均失血量和子宫切除率低于补救性栓塞亚组(1350 mL对3600 mL,60.0%对66.7%,P<0.05)。

结论

妊娠晚期胎盘植入患者可能发生严重产后出血,子宫切除率高。剖宫产术前或术中采用选择性动脉栓塞术可减少失血量和子宫切除率,但不能完全避免。

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