Kunz F, Pechlaner C, Tabarelli M, Sölder E, Zwierzina W D
Department of Internal Medicine, University of Innsbruck, Austria.
Am J Obstet Gynecol. 1990 Jul;163(1 Pt 2):417-20. doi: 10.1016/0002-9378(90)90593-v.
Routine coagulation laboratory tests, clotting times in native (not anticoagulated) whole blood, platelet-rich and platelet-poor plasma, and recalcification times in citrated whole blood, platelet-rich and platelet-poor plasma were performed in 14 healthy premenopausal women. Blood was taken before and after one or two cycles of low-dose oral contraceptives. After oral contraceptives a reduction in clotting time in native platelet-rich plasma and activated partial thromboplastin time were observed. Recalcification times in whole blood and platelet-rich plasma were shorter than clotting times in their native counterparts. The observed changes are compatible with a procoagulant effect seen soon after the start of oral contraceptive use. The absence of these changes in the recalcification times in citrate systems suggests a masking effect of citrate. The reduction in clotting times in native platelet-rich but not in platelet-poor plasma indicates that the hypercoagulability in oral contraceptives users is mainly related to platelets.
对14名健康的绝经前女性进行了常规凝血实验室检测，包括测定天然（未抗凝）全血、富血小板血浆和贫血小板血浆的凝血时间，以及枸橼酸化全血、富血小板血浆和贫血小板血浆的再钙化时间。在服用一或两个周期的低剂量口服避孕药前后采集血液。服用口服避孕药后，观察到天然富血小板血浆的凝血时间和活化部分凝血活酶时间缩短。全血和富血小板血浆的再钙化时间比其天然对应物的凝血时间短。观察到的这些变化与开始使用口服避孕药后不久出现的促凝作用相符。枸橼酸盐系统中再钙化时间没有这些变化，提示枸橼酸盐有掩盖作用。天然富血小板血浆而非贫血小板血浆的凝血时间缩短表明，口服避孕药使用者的高凝状态主要与血小板有关。
