Morozova T E, Andrushchishina T B, Antipova E K
Ter Arkh. 2013;85(3):118-24.
The paper presents data on the pharmacokinetics of the nonsteroidal anti-inflammatory drug ibuprofen and a review of the evidence base that suggests its clinical efficacy and safety in different categories of patients and discusses new, potentially possible indications for the use of this drug. Ibuprofen has marked anti-inflammatory, analgesic, and antipyretic effects, which along with its good tolerability, predictability of side effects, and a low risk of complications, allows it to be widely use in clinical practice. There are various ibuprofen formulations on the drug market. There may be not only an oral formulation of ibuprofen, but its topical (gel), rectal (suppositories), and parenteral (solution for intravenous injection) ones. More than 40 years' experience with ibuprofen used as an over-the-counter drug in wide clinical practice in approximately 80 countries worldwide serves as an illustrative example of the efficacy and safety of this agent.
本文介绍了非甾体抗炎药布洛芬的药代动力学数据，并综述了表明其在不同类别患者中的临床疗效和安全性的证据基础，还讨论了该药物使用的新的、潜在的可能适应症。布洛芬具有显著的抗炎、镇痛和解热作用，再加上其良好的耐受性、副作用的可预测性以及较低的并发症风险，使其能够在临床实践中广泛应用。药品市场上有多种布洛芬制剂。不仅有布洛芬的口服制剂，还有其外用（凝胶）、直肠（栓剂）和肠胃外（静脉注射溶液）制剂。在全球约80个国家的广泛临床实践中，布洛芬作为非处方药使用已有40多年的经验，这说明了该药物的有效性和安全性。
