Bijjaragi S, Kulkarni V, Suresh K K, Chatura K R, Kumar P
Department of Pathology JIM Medical College, Davangere, Karnataka, India, 577004.
Indian J Lepr. 2012 Oct-Dec;84(4):271-5.
Clinical and histopathological correlative study was carried out in 171 cases of leprosy using the criteria laid down by Ridley and Jopling. There was male preponderance in the study with majority of patients (35.7%) in the age goup of 21-30 years. The overall concordance between the clinical and histopathological diagnosis was 57.3%. Maximum concordance was seen in the polar ends of the spectrum with 76.9% in LL and 75.0% in TT. The concordance rate was lower in the borderline groups with 57.3% in BT, 40.0% in BL and least concordance of 16.7% in BB. However the concordance for IL was higher than the borderline groups with 66.7%. Cases in borderline group are in continuously changing immunological spectrum. Histological classification because of its definitive features gives a better indication than clinical classification for any recent shift of a case in the spectrum. Therefore skin biopsy should be done in all cases for correct classification of leprosy.
采用里德利（Ridley）和乔普林（Jopling）制定的标准，对171例麻风病患者进行了临床与组织病理学相关性研究。该研究中男性居多，大多数患者（35.7%）年龄在21至30岁之间。临床诊断与组织病理学诊断的总体一致性为57.3%。在光谱的两极一致性最高，LL型为76.9%，TT型为75.0%。边缘型组的一致性率较低，BT型为57.3%，BL型为40.0%，BB型一致性最低，为16.7%。然而，中间界线类（IL）的一致性高于边缘型组，为66.7%。边缘型组的病例处于不断变化的免疫光谱中。由于组织学分类具有明确特征，对于病例在光谱中的任何近期变化，它比临床分类能提供更好的指示。因此，为了正确分类麻风病，所有病例均应进行皮肤活检。
