Junttila Ilkka, Meri Seppo, Rämet Mika
VACTIA-Tutkimuslaboratorio, Tampereen Yilopisto, Lääketieteen Yksikkö FIMLAB OY, Klininen Mikrobiologia.
Duodecim. 2013;129(7):705-11.
The function of inflammasome in the cell is to sense intracellular danger signals and--perhaps as the last cry of distress of a cell invaded by a microorganism--at an emergency situation to release interleukins (IL) outside of the cell, causing an inflammatory reaction and fever and also leads to an elevation of CRP. In a hopeless situation inflammasome-regulated pyroptosis is started. Disturbed action of inflammasomes has been linked to the pathogenesis of various disorders such as gout, atherosclerosis, asbestosis and type 2 diabetes. As the pathogenetic mechanisms of such diseases become clear, improved treatments for them may also become available.
细胞内炎性小体的功能是感知细胞内的危险信号，并且——或许作为被微生物入侵细胞的最后求救信号——在紧急情况下将白细胞介素（IL）释放到细胞外，引发炎症反应和发热，还会导致C反应蛋白（CRP）升高。在绝望的情况下，炎性小体调节的细胞焦亡就会启动。炎性小体的功能紊乱与多种疾病的发病机制有关，如痛风、动脉粥样硬化、石棉沉着病和2型糖尿病。随着此类疾病发病机制的明确，针对它们的改进治疗方法也可能会出现。
