Schwilden H
Medizinische Fakultät, Universität Bonn.
Ann Fr Anesth Reanim. 1990;9(3):265-8. doi: 10.1016/s0750-7658(05)80184-4.
Organ failure modifies the pharmacokinetics of drugs and usually requires a decrease in their dosage. A decrease in cardiac output, in protein binding and extraction ratio, hepatic and renal insufficiency, a modification in acid-base balance are the main factors regulating pharmacokinetics of drugs used in anaesthesia and intensive therapy.
器官功能衰竭会改变药物的药代动力学，通常需要减少药物剂量。心输出量降低、蛋白结合率和提取率降低、肝肾功能不全以及酸碱平衡改变是调节麻醉和重症治疗中所用药物药代动力学的主要因素。
