Mori Y H, Kaminaga K, Ando T
Department of Mechanical Engineering, Keio University, Yokohama, Japan.
Ann Biomed Eng. 1990;18(3):285-98. doi: 10.1007/BF02368443.
This paper is concerned with a novel class of oxygenators which Li and Asher first proposed and called "liquid membrane oxygenators." They are different from usual bubble blood oxygenators in that oxygen bubbles are individually encapsulated by a liquid fluorocarbon membrane and dispersed in blood, instead of bare oxygen bubbles normally used. The fluorocarbon membrane's role is to prevent direct contact of blood with oxygen gas which can cause a rupture of red blood cells and denaturation of proteins in blood. We have attempted to produce encapsulated bubbles by use of a fine double-tube nozzle where oxygen is supplied through the inner tube of the nozzle while a liquid fluorocarbon is supplied through the annular space between the outer and the inner tubes. This device has been found to enable steady formation, both in pure water and in an aqueous solution of bovine serum albumin, of encapsulated bubbles of about 2 mm in diameter, which are far smaller than those produced by Li and Asher's original device. A comparative study of oxygenation of water (a substitute for blood) by encapsulated bubbles and by nonencapsulated bubbles indicates that the former is only slightly inferior to the latter.
本文关注的是一类新型的氧合器，这是李和阿舍首次提出并称之为“液膜氧合器”的。它们与通常的鼓泡式血液氧合器不同，在于氧气泡被液态氟碳膜单独包裹并分散在血液中，而不是通常使用的裸露氧气泡。氟碳膜的作用是防止血液与氧气直接接触，否则会导致红细胞破裂和血液中蛋白质变性。我们尝试通过使用精细的双管喷嘴来产生包裹气泡，其中氧气通过喷嘴的内管供应，而液态氟碳通过外管和内管之间的环形空间供应。已发现该装置能够在纯水和牛血清白蛋白水溶液中稳定形成直径约为2毫米的包裹气泡，这比李和阿舍的原始装置产生的气泡要小得多。对包裹气泡和未包裹气泡对水（血液替代品）进行氧合的比较研究表明，前者仅略逊于后者。
