State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.
Bioorg Med Chem Lett. 2013 Jul 1;23(13):3775-9. doi: 10.1016/j.bmcl.2013.04.093. Epub 2013 May 9.
A hydrophilic near-infrared (NIR) photosensitizer featuring a naphthalocyanine core and peripheral carboxylate acid groups was synthesized and characterized. Its photophysical and photochemical properties were studied and compared with phthalocyanine. Due to the extended π-conjugation, both the Q band and fluorescence emit of this naphthalocyanine bathochromically shift to NIR region. It also exhibits superior NIR photodynamic efficiency to phthalocyanine as evidenced by high efficiency in generating singlet oxygen (ΦΔ=0.66) and in vitro phototoxicity toward Hela human cervical cancer cells. Therefore, this novel naphthalocyanine could potentially be a NIR photosensitizer for photodynamic therapy.
合成并表征了一种具有萘酞菁核和外围羧酸基团的亲水性近红外（NIR）光敏剂。研究了其光物理和光化学性质，并与酞菁进行了比较。由于扩展的π共轭，该萘酞菁的 Q 带和荧光发射均红移至近红外区域。它还表现出优于酞菁的近红外光动力效率，这表现为高效产生单线态氧（ΦΔ=0.66）和对 Hela 人宫颈癌细胞的体外光毒性。因此，这种新型萘酞菁可能是一种用于光动力疗法的近红外光敏剂。
