用于前列腺癌研究的神经降压素拮抗剂 SR 48692 的合成。
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.
机构信息
Department of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom.
出版信息
Bioorg Med Chem. 2013 Jul 15;21(14):4378-87. doi: 10.1016/j.bmc.2013.04.075. Epub 2013 May 6.
PMID:23721919
Abstract
An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
摘要
一种改进的分子 SR 48692 的合成方法被提出，并将其用作神经降压素拮抗剂生物探针用于癌症研究。该制备方法包括许多增强的化学转化和策略，以克服原始化学路线中一些限制合成转化的问题。
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