Guenier C, Coibion M, Badr el Din A, Nogaret J M, Lorent I, Toueni E, Vanhoute P, Mattheiem W
Service de Chirurgie, Institut Jules-Bordet, Centre anticancéreux de l'Université Libre de Bruxelles, Belgique.
Ann Chir. 1990;44(5):392-5.
The authors reviewed the medical files of 100 patients with locally advanced breast cancer (stage III), treated in the department of surgery of the Institut Jules-Bordet between 1974 and 1988. All patients received preoperative radiotherapy (average total dose of 45 Grays). This preoperative irradiation was associated with chemotherapy in 74% of patients. All patients subsequently underwent surgery and a modified radical mastectomy was performed in 92% of cases. Our data analysis reveals an incidence of 25% of local wound infections, 34% of delayed wound healing, 63% of seroma formation and 22% of lymphoedema of the upper limb. The local postoperative morbidity appears to be increased in patients preoperatively irradiated. This indicates that preoperative chemotherapy may be preferable in these patients to minimise the local postoperative morbidity and its impact on the quality of life.
作者回顾了1974年至1988年间在朱尔斯·博尔代研究所外科接受治疗的100例局部晚期乳腺癌（III期）患者的病历。所有患者均接受了术前放疗（平均总剂量为45格雷）。74%的患者在术前放疗的同时接受了化疗。所有患者随后均接受了手术，92%的病例进行了改良根治性乳房切除术。我们的数据分析显示，局部伤口感染发生率为25%，伤口愈合延迟率为34%，血清肿形成率为63%，上肢淋巴水肿率为22%。术前接受放疗的患者术后局部发病率似乎有所增加。这表明，对于这些患者，术前化疗可能更可取，以尽量减少术后局部发病率及其对生活质量的影响。
