脂肪营养不良对接受高效抗逆转录病毒治疗的HIV感染者生活质量的影响。
Effect of Lipodystrophy on the Quality of Life among People Living with HIV (PLHIV) on Highly Active Antiretroviral Therapy.
作者信息
Shenoy Archana, Ramapuram John T, Unnikrishan Bhaskaran, Achappa Basavaprabhu, Madi Deepak, Rao Satish, Mahalingam Soundarya
机构信息
Kasturba Medical College, Manipal University, Mangalore, India
Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, India.
出版信息
J Int Assoc Provid AIDS Care. 2014 Sep-Oct;13(5):471-5. doi: 10.1177/2325957413488205. Epub 2013 May 30.
BACKGROUND
Lipodystrophy is a known adverse effect of highly active antiretroviral therapy (HAART). Lipodystrophy resulting in body dysmorphism can lower the quality of life (QoL) among HAART recipients. The main aim of our study was to find the effect of lipodystrophy on QoL among people living with HIV (PLHIV) on HAART.
METHODS
This cross-sectional study was conducted in a tertiary care hospital in south India. The participants were assessed for the presence of lipodystrophy. Their QoL was assessed using HIV-AIDS-targeted QoL questionnaire (HAT-QoL). Statistical analysis was carried out using SPSS version 11.5.
RESULTS
Lipodystrophy was present in 21 participants (42%). The QoL among individuals with lipodystrophy was found to be significantly lower in terms of disclosure worries (P = .023) and financial worries (P = .049).
CONCLUSIONS
Lipodystrophy adversely affects QoL among PLHIV. There is a need for studies analyzing factors that can potentially improve the QoL in such individuals.
背景
脂肪代谢障碍是高效抗逆转录病毒治疗（HAART）已知的一种不良反应。导致身体畸形的脂肪代谢障碍会降低接受HAART治疗者的生活质量（QoL）。我们研究的主要目的是确定脂肪代谢障碍对接受HAART治疗的艾滋病病毒感染者（PLHIV）生活质量的影响。
方法
这项横断面研究在印度南部的一家三级护理医院进行。对参与者进行脂肪代谢障碍评估。使用针对艾滋病病毒/艾滋病的生活质量问卷（HAT-QoL）评估他们的生活质量。使用SPSS 11.5版进行统计分析。
结果
21名参与者（42%）存在脂肪代谢障碍。在披露担忧（P = 0.023）和经济担忧（P = 0.049）方面，发现有脂肪代谢障碍的个体的生活质量显著较低。
结论
脂肪代谢障碍对PLHIV的生活质量有不利影响。需要开展研究分析可能改善此类个体生活质量的因素。
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