Department of Gastroenterology, Division of Southern Building, Chinese PLA General Hospital, Beijing - P.R. China.
Int J Biol Markers. 2013 Dec 17;28(4):e387-92. doi: 10.5301/jbm.5000034.
S100P has been shown to participate in processes of various human malignancies. In this study, we analyzed the tissue expression of S100P in gastric cancer and evaluated its significance.
We determined the S100P expression in 156 gastric cancer patients by quantitative RT-PCR. Tumor characteristics and overall survival (OS) for each patient were examined. In vitro experiments were conducted to examine whether ectopic expression of S100P modifies the proliferation and drug resistance of gastric cancer cells.
Higher expression of S100P occurred in human gastric cancer tissues in comparison with normal controls. Highly expressed S100P in gastric cancer was correlated with TNM stage and prognosis. The 5-year survival rate was significantly lower in patients with high levels of S100P expression than in patients with low levels of expression. Ectopic expression of S100P was associated with an increase in tumor cell proliferation and drug resistance.
The expression of S100P in human gastric cancer tissues was upregulated in comparison with normal controls. By establishing an association between S100P expression and shortened OS, increase in proliferation and drug resistance, this study indicates that S100P may be a useful prognostic marker for gastric cancer patients.
S100P 已被证明参与多种人类恶性肿瘤的发生发展过程。本研究分析了 S100P 在胃癌组织中的表达情况，并评估其意义。
我们通过定量 RT-PCR 检测了 156 例胃癌患者的 S100P 表达。检查了每位患者的肿瘤特征和总生存期（OS）。进行了体外实验以研究 S100P 的异位表达是否改变胃癌细胞的增殖和耐药性。
与正常对照相比，S100P 在人类胃癌组织中高表达。胃癌中高表达的 S100P 与 TNM 分期和预后相关。高 S100P 表达组的 5 年生存率明显低于低 S100P 表达组。S100P 的异位表达与肿瘤细胞增殖和耐药性增加有关。
与正常对照相比，S100P 在人胃癌组织中的表达上调。通过将 S100P 表达与缩短 OS、增加增殖和耐药性联系起来，本研究表明 S100P 可能是胃癌患者有用的预后标志物。
