两种诃子[诃子（诃黎勒）]剂型的肠道转运时间比较评价
A comparative evaluation of intestinal transit time of two dosage forms of Haritaki [Terminalia chebula Retz].
作者信息
Jirankalgikar Yogesh M, Ashok B K, Dwivedi Rambabu R
机构信息
Ph.D. Scholar, Department of Basic Principles, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
出版信息
Ayu. 2012 Jul;33(3):447-9. doi: 10.4103/0974-8520.108866.
Haritaki is praised as the best salutary drug which can be used in almost all ages of human life and is reputed for its Anulomana property. In Ayurveda, it has been mentioned that fruits of Haritaki when used in different forms give different type of actions. As the prime therapeutic utility of Haritaki is Anulomana, in the present study, two dosage forms of Haritaki fruits namely Churna and Vati were evaluated for intestinal transit time to evaluate its effect in two different dosage forms. Mature fruits were collected, authenticated, and processed as per classics to get Churna and Vati. Test drugs were administered in the dose of 550 mg/kg and evaluation on intestinal transit time was carried out by adopting kaolin expulsion test in mice. The results show that both the dosage forms of Haritaki significantly shortened intestinal transit time and between them Churna form is found to be better.
诃子被誉为最佳的滋补药物，几乎适用于人类生命的所有年龄段，并因其顺气特性而闻名。在阿育吠陀医学中，提到诃子果实以不同形式使用时会产生不同类型的作用。由于诃子的主要治疗效用是顺气，在本研究中，对诃子果实的两种剂型即散剂和丸剂进行了肠转运时间评估，以评价其在两种不同剂型中的效果。收集成熟果实，按照经典方法进行鉴定和加工，制成散剂和丸剂。以550毫克/千克的剂量给药受试药物，并通过采用高岭土排出试验对小鼠进行肠转运时间评估。结果表明，诃子的两种剂型均显著缩短了肠转运时间，且其中散剂效果更佳。
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