男变女易性癖者的皮质厚度增加。
Increased Cortical Thickness in Male-to-Female Transsexualism.
作者信息
Luders Eileen, Sánchez Francisco J, Tosun Duygu, Shattuck David W, Gaser Christian, Vilain Eric, Toga Arthur W
机构信息
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA.
出版信息
J Behav Brain Sci. 2012 Aug;2(3):357-362. doi: 10.4236/jbbs.2012.23040.
BACKGROUND
The degree to which one identifies as male or female has a profound impact on one's life. Yet, there is a limited understanding of what contributes to this important characteristic termed . In order to reveal factors influencing gender identity, studies have focused on people who report strong feelings of being the opposite sex, such as male-to-female (MTF) transsexuals.
METHOD
To investigate potential neuroanatomical variations associated with transsexualism, we compared the regional thickness of the cerebral cortex between 24 MTF transsexuals who had not yet been treated with cross-sex hormones and 24 age-matched control males.
RESULTS
Results revealed thicker cortices in MTF transsexuals, both within regions of the left hemisphere (i.e., frontal and orbito-frontal cortex, central sulcus, perisylvian regions, paracentral gyrus) and right hemisphere (i.e., pre-/post-central gyrus, parietal cortex, temporal cortex, precuneus, fusiform, lingual, and orbito-frontal gyrus).
CONCLUSION
These findings provide further evidence that brain anatomy is associated with gender identity, where measures in MTF transsexuals appear to be shifted away from gender-congruent men.
背景
一个人对自身男性或女性身份的认同程度对其生活有着深远影响。然而，对于构成这一被称为[此处原文缺失关键术语]的重要特征的因素，人们的了解有限。为了揭示影响性别认同的因素，研究聚焦于那些报告有强烈的异性身份感受的人群，比如男变女（MTF）变性者。
方法
为了研究与变性欲相关的潜在神经解剖学差异，我们比较了24名尚未接受跨性别激素治疗的男变女变性者与24名年龄匹配的对照男性的大脑皮质区域厚度。
结果
结果显示，男变女变性者的皮质更厚，包括左半球区域（即额叶和眶额皮质、中央沟、颞周区域、中央旁回）以及右半球区域（即中央前/后回、顶叶皮质、颞叶皮质、楔前叶、梭状回、舌回和眶额回）。
结论
这些发现进一步证明大脑解剖结构与性别认同有关，男变女变性者的测量结果似乎偏离了性别相符的男性。
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