风湿性疾病中血清基质金属蛋白酶-3水平升高：与滑膜炎及类固醇治疗的关系。
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment.
作者信息
Ribbens C, Martin y Porras M, Franchimont N, Kaiser M-J, Jaspar J-M, Damas P, Houssiau F A, Malaise M G
机构信息
Department of Rheumatology, University of Liége, Belgium.
出版信息
Ann Rheum Dis. 2002 Feb;61(2):161-6. doi: 10.1136/ard.61.2.161.
OBJECTIVE
To determine matrix metalloproteinase-3 (MMP-3) serum levels in patients with rheumatic diseases and to study the relation between MMP-3 and C reactive protein (CRP) levels.
METHODS
MMP-3 serum levels were determined by enzyme linked immunosorbent assay (ELISA) in (a) patients with active inflammatory rheumatic diseases: rheumatoid arthritis (RA), psoriatic arthritis, polymyalgia rheumatica, acute crystal arthritis, and ankylosing spondylitis; (b) patients with active inflammatory systemic diseases: cutaneo-articular or renal systemic lupus erythematosus (SLE), systemic sclerosis, and vasculitides; (c) patients with non-inflammatory rheumatic diseases: osteoarthritis and fibromyalgia; (d) critically ill patients without rheumatic diseases, representing an acute inflammatory control group; (e) healthy controls.
RESULTS
MMP-3 serum levels were significantly increased in patients with active RA, psoriatic arthritis, and polymyalgia rheumatica, whether treated or not by corticosteroids, and in female patients with acute crystal arthritis. MMP-3 serum levels were normal in steroid-free patients with active cutaneo-articular or renal SLE, systemic sclerosis, and vasculitides but were significantly increased in steroid treated patients. MMP-3 levels were normal in fibromyalgia, osteoarthritis, ankylosing spondylitis, and acute inflammatory controls. MMP-3 was significantly correlated with CRP in RA (r=0.5, p=0.0004) but not in any of the other disease groups.
CONCLUSIONS
MMP-3 serum levels are increased in inflammatory rheumatic diseases characterised by joint synovitis, such as RA, polymyalgia rheumatica, psoriatic arthritis, and acute crystal arthritis-that is, whether the diseases are acute or chronic, erosive or not. They are normal in SLE, systemic sclerosis, and vasculitides as well as in non-rheumatic inflammatory controls, but are significantly increased by steroids. These data strongly suggest that serum MMP-3 reflects synovial inflammation.
目的
测定风湿性疾病患者血清基质金属蛋白酶-3（MMP-3）水平，并研究MMP-3与C反应蛋白（CRP）水平之间的关系。
方法
采用酶联免疫吸附测定（ELISA）法测定以下人群的血清MMP-3水平：（a）活动性炎性风湿性疾病患者：类风湿关节炎（RA）、银屑病关节炎、风湿性多肌痛、急性晶体性关节炎和强直性脊柱炎；（b）活动性炎性全身性疾病患者：皮肤关节型或肾型系统性红斑狼疮（SLE）、系统性硬化症和血管炎；（c）非炎性风湿性疾病患者：骨关节炎和纤维肌痛；（d）无风湿性疾病的危重症患者，作为急性炎症对照组；（e）健康对照者。
结果
活动性RA、银屑病关节炎和风湿性多肌痛患者，无论是否接受皮质类固醇治疗，以及急性晶体性关节炎女性患者的血清MMP-3水平均显著升高。无类固醇治疗的活动性皮肤关节型或肾型SLE、系统性硬化症和血管炎患者的血清MMP-3水平正常，但接受类固醇治疗的患者血清MMP-3水平显著升高。纤维肌痛、骨关节炎、强直性脊柱炎和急性炎症对照组患者的MMP-3水平正常。在RA中，MMP-3与CRP显著相关（r = 0.5，p = 0.0004），但在其他任何疾病组中均无此相关性。
结论
在以关节滑膜炎为特征的炎性风湿性疾病中，如RA、风湿性多肌痛、银屑病关节炎和急性晶体性关节炎，血清MMP-3水平升高，即无论疾病是急性还是慢性、是否侵蚀性。在SLE、系统性硬化症和血管炎以及非风湿性炎症对照组中，血清MMP-3水平正常，但类固醇可使其显著升高。这些数据强烈表明血清MMP-3反映滑膜炎症。
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