BCL6 在正常和恶性淋巴细胞中的新效应功能和调节机制。
New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes.
机构信息
Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
出版信息
Curr Opin Immunol. 2013 Jun;25(3):339-46. doi: 10.1016/j.coi.2013.05.003. Epub 2013 May 30.
Abstract
The BCL6 oncogenic repressor is a master regulator of humoral immunity and B-cell lymphoma survival. Whereas much research has focused on its regulation and function in germinal center B-cells, its role in other mature lymphoid cell compartments is less clear. A novel role for BCL6 in follicular T helper cell development was recently uncovered. The latest discoveries reveal that BCL6 is also an important regulator of other specialized helper T-cell subsets within germinal centers, pre-germinal center events, and peripheral T-cell effector functions. Here, we review newly discovered roles for BCL6 in lymphocyte subsets residing within and outside of germinal centers, and discuss their implications with respect to the molecular mechanisms of BCL6 regulation and potential links to B and T-cell lymphomas.
摘要
BCL6 致癌抑制剂是体液免疫和 B 细胞淋巴瘤存活的主要调节因子。尽管许多研究都集中在其在生发中心 B 细胞中的调节和功能上，但它在其他成熟淋巴细胞区室中的作用尚不明确。最近发现了 BCL6 在滤泡辅助 T 细胞发育中的新作用。最新发现揭示了 BCL6 也是生发中心内和生发中心外的其他特化辅助 T 细胞亚群、生发中心前事件以及外周 T 细胞效应功能的重要调节因子。在这里，我们回顾了 BCL6 在生发中心内和生发中心外的淋巴细胞亚群中的新发现的作用，并讨论了它们与 BCL6 调节的分子机制及其与 B 和 T 细胞淋巴瘤的潜在联系的关系。
相似文献
1
New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes.BCL6 在正常和恶性淋巴细胞中的新效应功能和调节机制。
Curr Opin Immunol. 2013 Jun;25(3):339-46. doi: 10.1016/j.coi.2013.05.003. Epub 2013 May 30.
2
Association of Ig/BCL6 translocations with germinal center B lymphocytes in human lymphoid tissues: implications for malignant transformation.Ig/BCL6易位与人类淋巴组织生发中心B淋巴细胞的关联：对恶性转化的影响
Blood. 2006 Sep 15;108(6):2006-12. doi: 10.1182/blood-2006-03-011536. Epub 2006 May 25.
3
BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis.BCL6：生发中心反应的主要调节因子和 B 细胞淋巴瘤发生的关键癌基因。
Adv Immunol. 2010;105:193-210. doi: 10.1016/S0065-2776(10)05007-8.
4
Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers.人扁桃体 B 细胞淋巴瘤 6（BCL6）表达的 CD4+T 细胞亚群，专门在生发中心外辅助 B 细胞。
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):E488-97. doi: 10.1073/pnas.1100898108. Epub 2011 Aug 1.
5
Mechanisms of action of BCL6 during germinal center B cell development.生发中心B细胞发育过程中BCL6的作用机制。
Sci China Life Sci. 2015 Dec;58(12):1226-32. doi: 10.1007/s11427-015-4919-z. Epub 2015 Nov 14.
6
A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.Thpok 定向转录调控回路促进 Bcl6 和 Maf 表达以协调 T 滤泡辅助细胞分化。
Immunity. 2019 Sep 17;51(3):465-478.e6. doi: 10.1016/j.immuni.2019.06.023. Epub 2019 Aug 15.
7
BCL6 controls contact-dependent help delivery during follicular T-B cell interactions.BCL6 控制滤泡性 T 细胞相互作用过程中的依赖接触的辅助细胞传递。
Immunity. 2021 Oct 12;54(10):2245-2255.e4. doi: 10.1016/j.immuni.2021.08.003. Epub 2021 Aug 30.
8
Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells.BCL6 通过抑制 miR-31 稳定了人类滤泡辅助性 T 细胞的辅助功能。
Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12797-12802. doi: 10.1073/pnas.1705364114. Epub 2017 Nov 13.
9
The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis.BCL6原癌基因：在生发中心发育和淋巴瘤发生过程中起主导作用。
Pathol Biol (Paris). 2007 Feb;55(1):73-83. doi: 10.1016/j.patbio.2006.04.001. Epub 2006 Jul 3.
10
Cutting edge: T follicular helper cell differentiation is defective in the absence of Bcl6 BTB repressor domain function.前沿：在缺乏Bcl6 BTB抑制结构域功能的情况下，T滤泡辅助细胞分化存在缺陷。
J Immunol. 2015 Jun 15;194(12):5599-603. doi: 10.4049/jimmunol.1500200. Epub 2015 May 8.
引用本文的文献
1
Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma.突变型EZH2改变表观遗传网络并增加B细胞淋巴瘤中的表观遗传异质性。
PLoS Biol. 2025 Jun 12;23(6):e3003191. doi: 10.1371/journal.pbio.3003191. eCollection 2025 Jun.
2
Cross study transcriptomic investigation of Alzheimer's brain tissue discoveries and limitations.阿尔茨海默病脑组织的跨研究转录组学调查：发现与局限
Sci Rep. 2025 May 8;15(1):16041. doi: 10.1038/s41598-025-01017-y.
3
The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice.人乳寡糖 3-唾液酸乳糖可降低小鼠的低度炎症和动脉粥样硬化发展。
JCI Insight. 2024 Nov 8;9(21):e181329. doi: 10.1172/jci.insight.181329.
4
Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9.人类B细胞激活的多组学分析揭示了溶酶体BCAT1在B细胞受体和TLR9介导的mTOR过度激活中的关键作用。
Res Sq. 2024 May 30:rs.3.rs-4413958. doi: 10.21203/rs.3.rs-4413958/v1.
5
Mouse models of diffuse large B cell lymphoma.弥漫性大 B 细胞淋巴瘤的小鼠模型。
Front Immunol. 2023 Dec 6;14:1313371. doi: 10.3389/fimmu.2023.1313371. eCollection 2023.
6
Myeloid-CITED2 Deficiency Exacerbates Diet-Induced Obesity and Pro-Inflammatory Macrophage Response.髓系细胞 CITED2 缺乏症加剧饮食诱导的肥胖和促炎型巨噬细胞反应。
Cells. 2023 Aug 24;12(17):2136. doi: 10.3390/cells12172136.
7
The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation.穆利布瑞纳米病患者中的TRIM37变体使滤泡辅助性T细胞分化瘫痪。
Cell Discov. 2023 Aug 1;9(1):82. doi: 10.1038/s41421-023-00561-z.
8
Bcl6 drives stem-like memory macrophages differentiation to foster tumor progression.Bcl6 驱动干细胞样记忆巨噬细胞分化以促进肿瘤进展。
Cell Mol Life Sci. 2022 Dec 21;80(1):14. doi: 10.1007/s00018-022-04660-0.
9
Comparison of Morphological and Digital-Assisted Analysis for BCL6 Endometrial Expression in Women with Endometriosis.子宫内膜异位症女性中BCL6在子宫内膜表达的形态学与数字辅助分析比较
J Clin Med. 2022 Oct 19;11(20):6164. doi: 10.3390/jcm11206164.
10
BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis.BCL6，胎盘、子痫前期和子宫内膜异位症中的关键癌基因。
Hum Reprod Update. 2022 Nov 2;28(6):890-909. doi: 10.1093/humupd/dmac027.
本文引用的文献
1
Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms.Bcl-6 在免疫和炎症中的谱系特异性功能是由不同的生化机制介导的。
Nat Immunol. 2013 Apr;14(4):380-8. doi: 10.1038/ni.2543. Epub 2013 Mar 3.
2
The Bcl6 target gene microRNA-21 promotes Th2 differentiation by a T cell intrinsic pathway.Bcl6 靶基因 microRNA-21 通过 T 细胞内在途径促进 Th2 分化。
Mol Immunol. 2013 Jul;54(3-4):435-42. doi: 10.1016/j.molimm.2013.01.006. Epub 2013 Feb 13.
3
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.整合表观基因组分析鉴定成人 B 急性淋巴细胞白血病的生物标志物和治疗靶点。
Cancer Discov. 2012 Nov;2(11):1004-23. doi: 10.1158/2159-8290.CD-12-0208. Epub 2012 Oct 29.
4
Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function.Bcl6 通过抑制 Gata3 功能来控制调节性 T 细胞的 Th2 炎症活性。
J Immunol. 2012 Nov 15;189(10):4759-69. doi: 10.4049/jimmunol.1201794. Epub 2012 Oct 10.
5
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.B 和 T 细胞通过白细胞介素 6、白细胞介素 21 以及转录激活因子和共激活因子 Oct2 和 OBF-1 协同作用于抗病毒反应。
J Exp Med. 2012 Oct 22;209(11):2049-64. doi: 10.1084/jem.20111504. Epub 2012 Oct 8.
6
Bcl6 expression specifies the T follicular helper cell program in vivo.Bcl6 表达在体内特异性规定滤泡辅助性 T 细胞程序。
J Exp Med. 2012 Sep 24;209(10):1841-52, S1-24. doi: 10.1084/jem.20120219. Epub 2012 Sep 17.
7
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation.转录因子 IRF4 通过滤泡辅助性 T 细胞分化决定生发中心的形成。
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8664-9. doi: 10.1073/pnas.1205834109. Epub 2012 May 2.
8
Roles of BCL6 in normal and transformed germinal center B cells.BCL6 在正常和转化的生发中心 B 细胞中的作用。
Immunol Rev. 2012 May;247(1):172-83. doi: 10.1111/j.1600-065X.2012.01112.x.
9
Differentiation of germinal center B cells and follicular helper T cells as viewed by tracking Bcl6 expression dynamics.通过追踪 Bcl6 表达动态观察生发中心 B 细胞和滤泡辅助 T 细胞的分化。
Immunol Rev. 2012 May;247(1):120-32. doi: 10.1111/j.1600-065X.2012.01120.x.
10
The development and fate of follicular helper T cells defined by an IL-21 reporter mouse.IL-21 报告鼠定义滤泡辅助 T 细胞的发育和命运。
Nat Immunol. 2012 May;13(5):491-8. doi: 10.1038/ni.2261.
Zotero 插件