Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Curr Opin Immunol. 2013 Jun;25(3):339-46. doi: 10.1016/j.coi.2013.05.003. Epub 2013 May 30.
The BCL6 oncogenic repressor is a master regulator of humoral immunity and B-cell lymphoma survival. Whereas much research has focused on its regulation and function in germinal center B-cells, its role in other mature lymphoid cell compartments is less clear. A novel role for BCL6 in follicular T helper cell development was recently uncovered. The latest discoveries reveal that BCL6 is also an important regulator of other specialized helper T-cell subsets within germinal centers, pre-germinal center events, and peripheral T-cell effector functions. Here, we review newly discovered roles for BCL6 in lymphocyte subsets residing within and outside of germinal centers, and discuss their implications with respect to the molecular mechanisms of BCL6 regulation and potential links to B and T-cell lymphomas.
BCL6 致癌抑制剂是体液免疫和 B 细胞淋巴瘤存活的主要调节因子。尽管许多研究都集中在其在生发中心 B 细胞中的调节和功能上，但它在其他成熟淋巴细胞区室中的作用尚不明确。最近发现了 BCL6 在滤泡辅助 T 细胞发育中的新作用。最新发现揭示了 BCL6 也是生发中心内和生发中心外的其他特化辅助 T 细胞亚群、生发中心前事件以及外周 T 细胞效应功能的重要调节因子。在这里，我们回顾了 BCL6 在生发中心内和生发中心外的淋巴细胞亚群中的新发现的作用，并讨论了它们与 BCL6 调节的分子机制及其与 B 和 T 细胞淋巴瘤的潜在联系的关系。
