Department of Pathology & Laboratory Medicine and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Curr Opin Cell Biol. 2013 Aug;25(4):495-505. doi: 10.1016/j.ceb.2013.04.008. Epub 2013 May 29.
Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular compartments with unique composition, morphology and structure that share some features with endosomes and lysosomes and that function in varied processes such as pigmentation, hemostasis, lung plasticity and immunity. In recent years, studies of genetic diseases in which LRO functions are compromised have provided new insights into the mechanisms of LRO biogenesis and the regulated secretion of LRO contents. These insights have revealed previously unappreciated specialized endosomal sorting processes in all cell types, and are expanding our views of the plasticity of the endosomal and secretory systems in adapting to cell type-specific needs.
溶酶体相关细胞器 (LROs) 由一组具有独特组成、形态和结构的细胞类型特异性亚细胞区室组成，它们与内体和溶酶体具有一些共同特征，并在各种过程中发挥作用，如色素沉着、止血、肺可塑性和免疫。近年来，对 LRO 功能受损的遗传疾病的研究为 LRO 生物发生和 LRO 内容的调节分泌的机制提供了新的见解。这些见解揭示了所有细胞类型中以前未被重视的特殊内体分选过程，并扩展了我们对内体和分泌系统可塑性的认识，以适应细胞类型特异性的需求。
