人脑中的肌醇磷脂水解；腺苷对组胺反应的抑制作用。
Inositol phospholipid hydrolysis in human brain; adenosine inhibition of the response to histamine.
作者信息
Kendall D A, Firth J L
机构信息
Department of Physiology & Pharmacology, Queen's Medical Centre, Nottingham.
出版信息
Br J Pharmacol. 1990 May;100(1):37-40. doi: 10.1111/j.1476-5381.1990.tb12048.x.
Abstract
- Inositol phospholipid hydrolysis was examined in human cerebral cortex slices by a [3H]-inositol prelabelling assay. 2. Enhancement of [3H]-inositol phosphates accumulation was observed in the presence of carbachol, noradrenaline, histamine, 5-hydroxytryptamine (5-HT) and depolarizing concentrations of KCl. 3. Despite having no effect alone, adenosine (and its analogue 2-chloroadenosine) selectively inhibited the direct response to histamine. 4. The inhibition due to adenosine was antagonized by theophylline, but not by 8-cyclopropyltheophylline.
摘要
- 通过[3H]-肌醇预标记测定法检测了人大脑皮层切片中的肌醇磷脂水解。2. 在存在卡巴胆碱、去甲肾上腺素、组胺、5-羟色胺（5-HT）和去极化浓度的氯化钾时，观察到[3H]-肌醇磷酸积累增强。3. 腺苷（及其类似物2-氯腺苷）虽单独无作用，但能选择性抑制对组胺的直接反应。4. 腺苷引起的抑制作用可被茶碱拮抗，但不能被8-环丙基茶碱拮抗。
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