Mazzanti Gabriela, Di Sotto Antonella, Di Giacomo Silvia, Durazzi Federico, Mariani Paola, Nicoletti Marcello, Mammola Caterina Loredana, Vitalone Annabella
Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy.
Exp Toxicol Pathol. 2013 Nov;65(7-8):1117-20. doi: 10.1016/j.etp.2013.05.002. Epub 2013 May 29.
The present study assessed the ability of Chelidonium majus to potentiate the hepatic effect of a sub-toxic dose of acetaminophen, in rats.
C. majus, when administered alone, did not alter the liver function parameters in male, whereas an increase in fibrinogen level was found in female rats. Moreover, it did not affect the hepatic histomorphology in both male and female rats. The sub-toxic dose of acetaminophen induced: a significant increase in activated partial thromboplastin time in both genders, a focal hepatocellular necrosis with minor lymphocytes infiltrate and a slight but significant increase in total bilirubin, AST, and ALT in male rats, and in prothrombin time in female rats. The co-administration of C. majus did not increase the effects induced by acetaminophen, in both genders.
C. majus does not modify the hepatic effects of acetaminophen in our in vivo experimental model.
本研究评估了白屈菜在大鼠体内增强亚毒性剂量对乙酰氨基酚肝脏效应的能力。
单独给予白屈菜时，雄性大鼠的肝功能参数未发生改变，而雌性大鼠的纤维蛋白原水平有所升高。此外，它对雄性和雌性大鼠的肝脏组织形态均无影响。亚毒性剂量的对乙酰氨基酚可导致：两性的活化部分凝血活酶时间显著增加，雄性大鼠出现局灶性肝细胞坏死并伴有少量淋巴细胞浸润，总胆红素、天冬氨酸转氨酶和丙氨酸转氨酶略有但显著升高，雌性大鼠的凝血酶原时间延长。白屈菜与对乙酰氨基酚联合给药后，在两性中均未增强对乙酰氨基酚所诱导的效应。
在我们的体内实验模型中，白屈菜不会改变对乙酰氨基酚的肝脏效应。
