Kobashi M, Adachi A
Department of Physiology, University of Okayama, School of Dentistry, Japan.
Brain Res Bull. 1990 Jun;24(6):775-8. doi: 10.1016/0361-9230(90)90139-q.
This study was performed to examine projection of nucleus tractus solitarii (NTS) neurons to the caudal ventrolateral medulla (cVLM) in rats. One hundred and seven neurons that responded antidromically to electrical stimulation of the cVLM were recorded within the NTS. Electrical stimulation of the hepatic branch of the vagus nerve (hepatic vagus) elicited facilitation on 62 neurons (facilitatory neurons) and suppression on 6 neurons (suppressed neurons). Effect of portal infusion of hypertonic saline was examined on 44 facilitatory and 4 suppressed neurons. Twelve facilitatory and 2 suppressed neurons showed a decrease in the discharge rate. One suppressed neuron showed an increase in the discharge rate. It is concluded that hepatoportal osmoreceptive signals are conveyed from the NTS to the cVLM. The responses are mostly characterized by the decrease in the discharge rate by portal infusion of hypertonic saline.
本研究旨在检测大鼠孤束核（NTS）神经元向尾侧腹外侧延髓（cVLM）的投射。在NTS内记录到107个对cVLM电刺激产生逆向反应的神经元。电刺激迷走神经肝支（肝迷走神经）对62个神经元产生易化作用（易化性神经元），对6个神经元产生抑制作用（抑制性神经元）。对44个易化性神经元和4个抑制性神经元检测了门静脉输注高渗盐水的效应。12个易化性神经元和2个抑制性神经元放电率降低。1个抑制性神经元放电率增加。得出的结论是，肝门静脉渗透压感受信号从NTS传导至cVLM。这些反应大多表现为门静脉输注高渗盐水后放电率降低。
