Zeng Qingchao, Yuan Yan, Li Pei, Chen Tong
Department of Hematology, Huashan Hospital, Fudan University, China.
Intern Med. 2013;52(11):1227-33. doi: 10.2169/internalmedicine.52.9505.
Spontaneous remission (SR) in patients with acute myeloid leukemia (AML) is rare. We herein present two such cases. The first case was of AML-M2 accompanied by a bone marrow cytogenetic analysis revealing 46, XY, t(8;21)(q22,q22). The second case was of isolated cutaneous myeloid sarcoma (MS) that progressed to AML within seven months. Both of the patients had symptoms of infection and anemia and were therefore treated with antibiotics and transfusions. The SR lasted for two months and one month, respectively. Currently, the mechanisms underlying SR remain ambiguous. Possible underlying mechanisms with a review of the related literature are discussed.
急性髓系白血病（AML）患者的自发缓解（SR）较为罕见。我们在此报告两例此类病例。第一例为AML-M2，骨髓细胞遗传学分析显示为46，XY，t(8;21)(q22,q22)。第二例为孤立性皮肤髓系肉瘤（MS），在七个月内进展为AML。两名患者均有感染和贫血症状，因此接受了抗生素治疗和输血。自发缓解分别持续了两个月和一个月。目前，自发缓解的潜在机制仍不明确。本文讨论了可能的潜在机制并对相关文献进行了综述。
