Department of Otolaryngology - Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.
Head Neck. 2014 Feb;36(2):257-65. doi: 10.1002/hed.23302. Epub 2013 Jun 1.
Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load.
A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009. P16 expression status by immunohistochemistry and HPV DNA viral load by quantitative polymerase chain reaction (qPCR) were evaluated on routine pretreatment tumor samples.
One hundred thirty-three patients (94 men and 39 women) were included in the study. Mean age was 59 years. One hundred twenty-two lesions (92%) were localized to lymphoid areas. Sixty-seven patients (50%) were p16+, and 87 patients (65%) harbored HPV DNA. The p16+/HPV DNA+ profile (48%) was associated with the most favorable prognosis. HPV16 was responsible for the majority of the infections (89%).
HPV is common among oropharyngeal SCC in France, and acts as an independent prognostic factor.
人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌（SCC）与良好的生存相关。本研究的目的是通过 p16 表达状态和致癌 HPV DNA 病毒载量来评估 HPV 感染的流行率和预后意义。
对 2007 年 1 月至 2009 年 6 月期间治疗的所有口咽 SCC 患者进行回顾性图表审查。在常规的预处理肿瘤样本中，通过免疫组织化学评估 p16 表达状态，通过定量聚合酶链反应（qPCR）评估 HPV DNA 病毒载量。
本研究纳入了 133 名患者（94 名男性和 39 名女性）。平均年龄为 59 岁。122 个病变（92%）位于淋巴区域。67 名患者（50%）p16+，87 名患者（65%）携带 HPV DNA。p16+/HPV DNA+ 表型（48%）与最佳预后相关。HPV16 是大多数感染的罪魁祸首（89%）。
HPV 在法国口咽 SCC 中很常见，并且是独立的预后因素。
