Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Heidelberg, Germany.
Int J Eat Disord. 2013 Nov;46(7):721-8. doi: 10.1002/eat.22143. Epub 2013 Jun 3.
To investigate neuropsychological mechanisms of impulsivity in patients with bulimia nervosa (BN) and binge-eating disorder (BED).
Nineteen BN patients and 31 age- and body-mass-index (BMI)-matched healthy controls (c-BN) as well as 54 overweight and obese BED patients and 43 age- and BMI-matched healthy controls (c-BED) were investigated using an inhibitory control task (stop signal task, SST) and a decision-making under risk task (game of dice task, GDT).
Compared to c-BN, BN patients demonstrated significant greater stop signal reaction times in the SST, but no differences for the frequency of risky decisions in the GDT. BED patients did not differ from c-BED in the SST or the GDT.
BN but not BED patients differed from their respective control groups concerning the "stopping" component of impulsivity. These differences in motor inhibition may contribute to the behavioral distinctions in binge-eating behavior between BN and BED.
探究神经性贪食症（BN）和暴食障碍（BED）患者冲动的神经心理学机制。
研究采用抑制控制任务（停止信号任务，SST）和风险决策任务（骰子游戏任务，GDT）对 19 名 BN 患者、31 名年龄和体重指数（BMI）匹配的健康对照者（c-BN）以及 54 名超重和肥胖的 BED 患者和 43 名年龄和 BMI 匹配的健康对照者（c-BED）进行了调查。
与 c-BN 相比，BN 患者在 SST 中的停止信号反应时间显著延长，但在 GDT 中的风险决策频率没有差异。BED 患者在 SST 或 GDT 中与 c-BED 没有差异。
与各自的对照组相比，BN 患者而非 BED 患者在冲动的“停止”成分方面存在差异。这种运动抑制方面的差异可能导致 BN 和 BED 患者在暴食行为方面的行为差异。
